Dr David Sinclair talks about his skin care routine, including moisturizer contains resveratrol, hyaluronic acid and Betaine(TMG) made by his lab, 0.5% Retinol A lotion and a small peptide in this clip.

Retinol is the scientific name for Vitamin A. Retinol is known to irritate the skin due to its powerful exfoliating and cell renewing ability. High concentration of Retinol A may cause redness, irritation, dryness, and/or peeling, so please be very cautious when using and mix with lotion/cream. Also apply first on a small area of skin to test a few days first as seems irritation occurs after 3-4 days. Stop using when the irritation occurs. Avoid too close to eyes area. Always consult with your Doctor before start any treatment.

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.

Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives.

Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others.
He is also co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time's Top 50 in healthcare in 2018.

Dr. Sinclair’s official lifespan podcast https://www.youtube.com/c/DavidSinclairPodcast.
___________________________________________
DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.


#DavidSinclair #Retinol #HyaluronicAcid #LookYounger #NMN #Resveratrol #Quercetin #Fisetin #senolytics #OliveOil #Sirtuin #HIIT #Resveratrol #aging #Lifespan #NMN #NR #Spermidine #Metformin #Berberine #ReverseAging #Epigenetic #OleicAcid #NMN #NAD #Sirtuins #Fasting #Longevity #RestoreYouth #Reprogramming #DavidSinclair #DrSinclairLab #Healthspan #Younger #antiaging #DrSinclair #NAD #longevity #Bioscience #Epigenome

This episode is sponsored by Future. Future makes one on one training available to our audience for just $19 Go to https://tryfuture.co/impact to sign up to crush your fitness goals!

Are we closer to becoming biologically immortal? What would you strive to do or dream of if you could extend your life to even 150 years? Until recently the idea of longevity felt more like reaching your 90s and possibly 100 at best, and if you manage to accomplish that goal, a high quality of life would be best and expected. But what if you could extend your lifespan by even 10 years? Making sure that those years are exciting and meaningful would be a priority. Dr.David Sinclair, a world-renowned geneticist, is joining Tom in this episode to break down exactly why it is that we age on a cellular level, and what is now becoming possible in terms of slowing down our biological clock and even possibly reversing our biological age. If you want to know what you can do to start improving the quality of your aging life and stay younger longer this episode is for you, and you’ll want to check out Dr. David Sinclair’s newest podcast, Lifespan (link below).


SHOW NOTES:

0:00 | Introduction to David Sinclair
0:28 | Why We Age
9:40 | What Goes Wrong With Aging
23:44 | How to Reverse Aging
37:35 | Face Adversity
45:37 | How Metformin Works
55:02 | Lifestyle for Longevity

“We could have reversed aging just by making all cells a stem cell, we have the technology to do that.” [23:43]

“So we're reversing the aging of the eye, that's not hard at all, but we can reverse the age of the liver, the skin, other labs are doing the spleen, thymus, through this method.” [31:13]

“Humanity lucked out that we can actually do this and that there's a backup copy of youth in each of our cells that can be tapped into.” [32:03]

“We don't think about what it's like at the end, it is not fun. It's not typically like, Oh, you just go to sleep. Those are the lucky ones.” [36:39]

“The main concept that I think we all need to remember is that our bodies respond well to perceived adversity.” [38:55]

Follow David Sinclair:
Website: https://sinclair.hms.harvard.edu/
YouTube: https://www.youtube.com/davidsinclairpodcast
Podcast: https://anchor.fm/lifespan
Instagram: https://www.instagram.com/davidsinclairphd/
Twitter: https://twitter.com/davidasinclair
Facebook: https://www.facebook.com/davidsinclairphd

Descubre al hombre de 55 años… que parece de 30.David Sinclair, genetista de Harvard y una de las mayores autoridades en el mundo del antienvejecimiento, ha dedicado su vida a revertir el reloj biológico.

¿Te atreverías a seguir su estilo de vida?
Guarda este video y compártelo con alguien que quiera vivir más… y mejor.

#belleza #antiaging #antiagingsecrets #juventud #bienestar

Watch the full episode here - https://youtu.be/J736mfy7KEg

From Modern Wisdom Podcast episode #066 PROFESSOR DAVID SINCLAIR | Can Humans Live For 1000 Years?

-

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Biologist David Sinclair from Harvard Medical School on alphaproteobacteria, reactive oxygen species, and why the nucleus and the mitochondrial genome are like a married couple.

Read the text version here: https://serious-science.org/ro....le-of-mitochondria-i

Get a bigger picture: 
1. Aging and Disease — David Gems: https://youtu.be/br9L8Py9taU
2. Reversible Aging — David Sinclair: https://youtu.be/YAIck1DUHHU
3. Molecular Cause of Aging — Vadim Gladyshev: https://youtu.be/YLfgoR2f89U

Follow us:
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Support us on Patreon to see more videos: https://www.patreon.com/SeriousScience

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/
Timestamps:
00:00 Intro
00:58 David Sinclair's information theory of aging
01:25 Yamanaka factors vs Sinclair's partial reprogramming
03:54 Cellular reprogramming studies in mice
05:59 Cellular reprogramming study progression
06:40 The first human anti-aging clinical trial by Sinclair
08:52 My thoughts on cellular reprogramming
09:20 Will this be another hype cycle by Sinclair

My 2026 longevity routine: https://youtu.be/OceysodInIo

Start rewinding your biological clock: https://www.siimland.co/course

P.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

Tom Bilyeu and Dr. David Sinclair discuss why we age on Health Theory. Watch the full video here: https://www.youtube.com/watch?v=IEz1P4i1P7s&feature=youtu.be

Follow Tom Bilyeu:
Instagram: http://bit.ly/2s9lU90
YouTube: http://bit.ly/2KWanAC
Podcast: https://spoti.fi/2xEloFL

🎞️ This Is A Clip From Figuring Out Episode 562
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• • •

Featuring - Dr. David Sinclair

In today’s episode, we sit down with Dr. David Sinclair, A.O., Ph.D., Longevity Scientist and Professor of Genetics, Harvard Medical School, to understand the science of aging and whether we can actually slow it down.

We discuss why our bodies age, what happens to our cells as we get older, and how genetics, lifestyle, and cellular health influence longevity. David explains the science behind reversing biological aging, the role of nutrition and exercise, and what emerging research could mean for extending both lifespan and healthspan.

The conversation also explores what we can do today to stay healthier for longer and where the science of longevity is heading.
• • •

About Raj Shamani
Raj Shamani is the Founder Of Figuring Out Media. He's an Entrepreneur, Content Creator, Investor, and a Renowned Keynote Speaker. Raj has emerged as one of the Youngest Influencers in the Indian creator economy.

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Raj Shamani Clips is your one-stop destination to become 1% smarter every day. This channel will help you grow daily so that you live and love better. We are on the mission to help everyone achieve their ‘Indian Dream’ through Figuring Out. We promise you that you will learn new things around business, marketing, politics and everything around India. Subscribe to our channel and grow with us.

#keepfiguringout

David Sinclair, a professor at Harvard Medical School, has said that he thinks the first person who will live to the age of 150 is already alive today. During a panel discussion about longevity at the TIME100 Health Leadership Forum in New York City on Sept. 10, TIME executive editor Nikhil Kumar asked Sinclair what motivated him to say that.

“Children born today will live into the 22nd century, and just think about in the last five years what’s happened to our world; it’s barely recognizable when it comes to AI and even the healthcare world,” Sinclair replied. “So, in the 22nd century, children born today are going to have access to technologies that we literally cannot even imagine now.”

Sinclair was joined on stage by Jennifer Garrison, a neuroscientist with expertise in the women’s health biotech field, and Jack Jia, the founder and CEO of Musely, a telehealth platform aimed at expanding access to personalized prescription care that sponsored the event on Sept. 10.

Read more: https://time.com/collection/ti....me100-leadership-for

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0:00 Could Today’s Children Live to 150 Years Old?
1:49 Why Children Born Today Could Live Into the 22nd Century
2:25 Women’s Health, Ovaries & Longevity Research
4:00 The Gender Data Gap in Medical Research
4:59 How Personalized Medicine Could Change Preventive Health
9:20 The Risks of Biohacking & Longevity Drugs
10:21 How AI Is Accelerating Aging Research
11:11 Can Scientists Reverse Aging in Human Cells?
12:51 Longevity Tests, Scans & Questionable Science
16:58 Has the Longevity Boom Moved Too Fast?
19:16 How Long Do Longevity Experts Want to Live?
23:01 Final Thoughts on Healthspan & Living Longer

#Longevity #HealthyAging

#meganoticias #chile #noticias #mega #ciencia #tecnología

David Sinclair, profesional de la escuela de medicina de la prestigiosa universidad norteamericana de Harvard, apunta a tratar la vejez como si fuera una enfermedad y así, encontrar "su cura".

SÍGUENOS EN:
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Dr. David Sinclair on The Truth About Age Reversal For centuries, aging has been accepted as an unavoidable part of life. But what if it could one day be treated?

At the World Governments Summit, Dr. David Sinclair, Professor of Genetics at Harvard Medical School, explores the science behind age reversal, the future of longevity, and the first human clinical trial designed to reverse aspects of aging.

As breakthroughs in biotechnology accelerate, this conversation examines how extending healthy lifespan could transform healthcare, economies, and the future of humanity.

Speaker: Dr. David Sinclair, Professor of Genetics, Harvard Medical School

The World Governments Summit is the world’s leading platform shaping the future of governments, innovation, and global cooperation. Bringing together world leaders, policymakers, innovators, and industry experts, the Summit explores the biggest global challenges and the transformative technologies shaping the future of humanity.

From artificial intelligence, digital transformation, and smart governance to sustainability, economic growth, and future-ready societies, the World Governments Summit drives meaningful conversations that inspire innovation, progress, and international collaboration.

Watch exclusive speeches, interviews, panel discussions, and key insights from one of the world’s most influential government and innovation platforms.

Subscribe for the latest updates on global leadership, emerging technologies, future trends, policy innovation, and international cooperation.

🔗 Visit the World Governments Summit Website for more updates:
https://www.worldgovernmentssummit.org/

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#WorldGovernmentsSummit #WGS #Worldgovsummit

🎞️ This Is A Clip From Figuring Out Episode 562
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• • •

Featuring - Dr. David Sinclair

In today’s episode, we sit down with Dr. David Sinclair, A.O., Ph.D., Longevity Scientist and Professor of Genetics, Harvard Medical School, to understand the science of aging and whether we can actually slow it down.

We discuss why our bodies age, what happens to our cells as we get older, and how genetics, lifestyle, and cellular health influence longevity. David explains the science behind reversing biological aging, the role of nutrition and exercise, and what emerging research could mean for extending both lifespan and healthspan.

The conversation also explores what we can do today to stay healthier for longer and where the science of longevity is heading.
• • •

About Raj Shamani
Raj Shamani is the Founder Of Figuring Out Media. He's an Entrepreneur, Content Creator, Investor, and a Renowned Keynote Speaker. Raj has emerged as one of the Youngest Influencers in the Indian creator economy.

To Know More,
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• • •


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About Raj Shamani Clips
Raj Shamani Clips is your one-stop destination to become 1% smarter every day. This channel will help you grow daily so that you live and love better. We are on the mission to help everyone achieve their ‘Indian Dream’ through Figuring Out. We promise you that you will learn new things around business, marketing, politics and everything around India. Subscribe to our channel and grow with us.

#keepfiguringout

Scientists like Prof Sinclair have evidence of speeding up, slowing, and even reversing aging.
Thanks to LastPass for sponsoring this video. Click here to start using LastPass: https://ve42.co/VeLP

What causes aging? According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes. Epigenetics allow different cell types to perform their specific functions - they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc. When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well.

To counter this decline, we can activate the body's own defenses against aging by stressing the body. Eat less, eat less protein, engage in intense exercise, experience uncomfortable cold. When the body senses existential threats it triggers longevity genes, which attempt to maintain the body to ensure its survival until good times return. This may be the evolutionary legacy of early bacteria, which established these two modes of living (repair and protect vs grow and reproduce). Scientists are uncovering ways to mimic stresses on the body without the discomfort of fasting. Molecules like NMN also trigger sirtuins to monitor and repair the epigenome. This may slow aging.

Reversing aging requires an epigenetic reset, which may be possible using Yamanaka factors. These four factors can revert an adult cell into a pluripotent stem cell. Prof. Sinclair used three of the four factors to reverse aging in the retinal cells of old mice. He found they could see again after the treatment.

Special thanks to:
Professor David Sinclair, check out his book "Lifespan: Why We Age & Why We Don't Have To"
Assistant Professor David Gold
Noemie Sierra (for polyp images)
Genepool Productions for telomere animations from Immortal: https://ve42.co/immortal
Epigenetics animations (DNA, histones, methylation etc) courtesy of: http://wehi.tv
Animation: Etsuko Uno
Art and Technical Direction: Drew Berry
Sound Design: Francois Tetaz & Emma Bortignon
Scientific Consultation: Marnie Blewitt
Courtesy of Walter and Eliza Hall Institute of Medical Research

Filming, editing and animation by Jonny Hyman and Derek Muller

Music from https://epidemicsound.com "Clearer Views" "Innovations" "A Sound Foundation" "Seaweed"
Additional music by Kevin MacLeod from https://incompetech.com "Marty Gots a Plan"

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• • •

Featuring - Dr. David Sinclair

In today’s episode, we sit down with Dr. David Sinclair, A.O., Ph.D., Longevity Scientist and Professor of Genetics, Harvard Medical School, to understand the science of aging and whether we can actually slow it down.

We discuss why our bodies age, what happens to our cells as we get older, and how genetics, lifestyle, and cellular health influence longevity. David explains the science behind reversing biological aging, the role of nutrition and exercise, and what emerging research could mean for extending both lifespan and healthspan.

The conversation also explores what we can do today to stay healthier for longer and where the science of longevity is heading.
• • •

About Raj Shamani
Raj Shamani is the Founder Of Figuring Out Media. He's an Entrepreneur, Content Creator, Investor, and a Renowned Keynote Speaker. Raj has emerged as one of the Youngest Influencers in the Indian creator economy.

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About Raj Shamani Clips
Raj Shamani Clips is your one-stop destination to become 1% smarter every day. This channel will help you grow daily so that you live and love better. We are on the mission to help everyone achieve their ‘Indian Dream’ through Figuring Out. We promise you that you will learn new things around business, marketing, politics and everything around India. Subscribe to our channel and grow with us.

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David Sinclair über Epigenetik, Lebensstil und die Medizin der Zukunft

Diese Folge ist auf Englisch! English see below.

In diesem Interview durfte ich mit Prof. David Sinclair sprechen. David Sinclair ist einer der weltweit führenden Wissenschaftler auf dem Gebiet der Altersforschung und Genetik. Als Professor an der Harvard Medical School hat er mit bahnbrechenden Studien zur epigenetischen Reprogrammierung und Langlebigkeit weltweite Bekanntheit erlangt. Sinclair ist Autor des Bestsellers Das Ende des Alterns und ein Verfechter eines gesunden Lebensstils, der Altern nicht nur verlangsamen, sondern möglicherweise sogar umkehren kann. Außerdem ist er Vorsitzender des wissenschaftlichen Beirats von Virtusan, einem Schweizer Startup-Unternehmen. Im Interview spricht David Sinclair über Strategien zur Lebensverlängerung, wissenschaftliche Durchbrüche in der Altersforschung und praktische Ansätze für ein gesundes, bewusstes Leben.


In dieser Folge sprechen wir u.a. über folgende Themen:
Wie unterscheidet sich das biologische Alter von David Sinclair von seinem chronologischen Alter, und welche Faktoren beeinflussen dieses?
Welche täglichen Routinen und Ernährungstipps empfiehlt Sinclair, um den Alterungsprozess zu verlangsamen?
Welche Rolle spielen Nahrungsergänzungsmittel und Medikamente in Sinclairs Ansatz zur Altersverlangsamung?
Wie wirkt sich Stress auf den Alterungsprozess aus und welche Strategien hat Sinclair zur Stressbewältigung entwickelt?
Welche wissenschaftlichen Paradigmen zur Alterung hat Sinclair im Laufe seiner Karriere miterlebt und hinterfragt?
Wie misst Sinclair den biologischen Zustand seines Körpers im Alltag, und welche Wearables verwendet er dafür?
Warum bevorzugt Sinclair NMN gegenüber NR und was ist der Hintergrund seiner Forschung an NAD-Booster-Molekülen?
Welche Erfahrungen hat Sinclair mit medizinischen Wirkstoffen wie Rapamycin und Metformin gesammelt?
Welche neuen Entwicklungen gibt es im Bereich der epigenetischen Reprogrammierung, und welche Anwendungen könnten diese haben?
Welche Vision hat Sinclair für eine Zukunft, in der Medikamente und chemische Cocktails den Alterungsprozess umkehren?

Weitere Informationen zu Prof. David Sinclair findest du hier:
https://sinclair.hms.harvard.e....du/people/david-sinc

Du interessierst dich für Gesunde Langlebigkeit (Longevity) und möchtest ein Leben lang gesund und fit bleiben, dann folge mir auch auf den sozialen Kanälen bei Instagram, TikTok, Facebook oder Youtube.
https://www.instagram.com/nina.ruge.official
https://www.tiktok.com/@nina.ruge.official
https://www.facebook.com/NinaRugeOffiziell
https://www.youtube.com/channe....l/UCOe2d1hLARB60z2hg

Disclaimer: Ich bin keine Ärztin und meine Inhalte ersetzen keine medizinische Beratung. Bei gesundheitlichen Fragen wende dich bitte an deinen Arzt/deine Ärztin.



In this interview, I had the pleasure of speaking with Prof. David Sinclair. David Sinclair is one of the world's leading scientists in the field of ageing research and genetics. As a professor at Harvard Medical School, he has gained worldwide recognition with groundbreaking studies on epigenetic reprogramming and longevity. Sinclair is the author of the bestselling book "Lifespan" and an advocate of healthy lifestyles that can not only slow down ageing, but possibly even reverse it. Furthermore, he is the chairman of science advisory board of Virtusan- a Swiss startup. In this interview, David Sinclair talks about strategies for prolonging life, scientific breakthroughs in ageing research and practical approaches to living a healthy, conscious life.

In this episode we talk about the following topics, among others:
How does David Sinclair's biological age differ from his chronological age, and what factors influence it?
What daily routines and dietary tips does Sinclair recommend to slow down the aging process?
What role do supplements and medication play in Sinclair's approach to slowing down ageing?
How does stress affect the ageing process and what strategies has Sinclair developed to manage stress?
What scientific paradigms on aging has Sinclair witnessed and challenged throughout his career?
How does Sinclair measure the biological state of his body in everyday life, and which wearables does he use for this?
Why does Sinclair prefer NMN to NR and what is the background to his research into NAD booster molecules?
What experience has Sinclair gained with medical agents such as rapamycin and metformin?
What new developments are there in the field of epigenetic reprogramming, and what applications might these have?
What is Sinclair's vision for a future in which drugs and chemical cocktails reverse the ageing process?

You can find more information about Prof. David Sinclair here:
https://sinclair.hms.harvard.e....du/people/david-sinc

Disclaimer: I am not a doctor and my content does not replace medical advice. If you have any health questions, please consult your doctor.

STY-148

🎞️ This Is A Clip From Figuring Out Episode 562
Watch The Full Episode Here - https://www.figuringout.co/link/fo-562

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• • •

Featuring - Dr. David Sinclair

In today’s episode, we sit down with Dr. David Sinclair, A.O., Ph.D., Longevity Scientist and Professor of Genetics, Harvard Medical School, to understand the science of aging and whether we can actually slow it down.

We discuss why our bodies age, what happens to our cells as we get older, and how genetics, lifestyle, and cellular health influence longevity. David explains the science behind reversing biological aging, the role of nutrition and exercise, and what emerging research could mean for extending both lifespan and healthspan.

The conversation also explores what we can do today to stay healthier for longer and where the science of longevity is heading.
• • •

About Raj Shamani
Raj Shamani is the Founder Of Figuring Out Media. He's an Entrepreneur, Content Creator, Investor, and a Renowned Keynote Speaker. Raj has emerged as one of the Youngest Influencers in the Indian creator economy.

To Know More,
Follow Raj Shamani On ⤵︎

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• • •


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About Raj Shamani Clips
Raj Shamani Clips is your one-stop destination to become 1% smarter every day. This channel will help you grow daily so that you live and love better. We are on the mission to help everyone achieve their ‘Indian Dream’ through Figuring Out. We promise you that you will learn new things around business, marketing, politics and everything around India. Subscribe to our channel and grow with us.

#keepfiguringout

Watch the full episode here - https://youtu.be/J736mfy7KEg

David Sinclair describes his longevity routine. From Modern Wisdom Podcast episode #066 PROFESSOR DAVID SINCLAIR | Can Humans Live For 1000 Years?

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#davidsinclair #longevity #nad

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Related episodes:

The True Story of David Sinclair's Longevity Lie: https://www.youtube.com/watch?v=xQrXs7CxIjk

DON'T Take Resveratrol Until You Watch This Video: https://youtu.be/MmIBdqsQYfw

Scientists Debate How to Live Longer & Longevity Drugs: https://youtu.be/EebH_taOlAA

An introduction to the study of RAPAMYCIN: https://youtu.be/czx_-DqnnrQ

In this episode, Matt and Nick react to investigative journalist and author Scott Carney's video describing what he calls "David Sinclair's longevity lie" in the context of David's longevity-focused entrepreneurial ventures. Matt shares his professional history with David, including his early interactions with David in Leonard Guarente's lab at the Massachusetts Institute of Technology (MIT) and scientific differences that emerged after Matt and colleagues were unable to reproduce a key result from David's work pertaining to resveratrol. Their discussion touches on some of David's scientific claims about age reversal, the role of institutions such as Harvard University in regulating scientific integrity, the potential for future interventions in healthspan and longevity, and the importance of separating personal feelings from scientific evaluation.

David, currently a professor in Harvard Medical School's Department of Genetics at the Paul F. Glenn Center for Biology of Aging Research, is a prominent geroscience researcher whose lab focuses on age-related epigenetic change, cellular reprograming, longevity drug discovery, mitochondrial fitness, reproductive aging, neurodegenerative disease, and the human secretome. He has received awards including the National Institutes of Health Nathan Shock Award, the Merck Prize, and the Australian Medical Research Medal, and was elected to TIME's 2014 “100 Most Influential People in the World" list. David conducted postdoctoral research at MIT and obtained a PhD in Molecular Genetics at the University of New South Wales.

0:00 Introduction
6:12 The video begins
7:21 Claims of immortality
8:26 The consequences of making unsubstantiated claims
10:23 A logical fallacy
15:04 Some clarifications about SIR2
17:23 TED Talks + getting information from credible sources
19:15 Setting the record straight on sirtuins and lifespan
22:19 Reproducible work from David's lab
24:02 GlaxoSmithKline's decision
25:42 Conflating the resveratrol story with sirtuin biology
26:10 A "buddy system" of reviewing papers
30:57 Andrew Huberman and Peter Attia + bashing the scientific enterprise
33:20 Show us the data
37:25 Why hasn't Harvard taken action?
41:41 Not a totally fake space
44:34 Relationship with the FDA
50:04 Matt's resignation from the Academy for Health & Lifespan Research
54:14 Immortality vs tackling the biology of aging
56:13 Closing thoughts
58:55 Looking at the comments

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.

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Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Watch the full interview with Dr. David Sinclair on YouTube 👉 https://youtu.be/8xA5L60DmuQ

Dr. David Sinclair is a leading world authority on aging and longevity. He is Professor of Genetics at Harvard Medical School.

David is the author of Lifespan: Why We Age - and Why We Don't Have To & the host of Lifespan podcast.

Subscribe to The Jesse Chappus Show on YouTube: https://www.youtube.com/@JesseChappus
(And be sure to hit the 🔔 to get notified when new videos are released!)

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Disclaimer: The opinions expressed in this video are those of the guest and are presented for informational purposes only. This content is not medical advice. Please consult your healthcare provider regarding any health-related decisions.

Over the past few decades, an abundance of scientific research has focused on resveratrol, a plant-based compound found in red grapes and peanuts. Much of this research has demonstrated that, at high doses, resveratrol exerts beneficial health effects – especially on the cardiovascular system – and has been shown to ameliorate the deleterious effects of an obesogenic diet in monkeys. Resveratrol is a "dirty molecule," however, known for its multiple cellular targets, so teasing out all the ramifications of its use has proven problematic. Furthermore, it is relatively unstable and demonstrates poor bioavailability in humans. In this clip, Dr. David Sinclair identifies some of the practical considerations of resveratrol supplementation and discusses his personal use of the compound.

This clip was taken from the FoundMyFitness interview with Dr. David Sinclair found at https://youtu.be/5DtWqzalEnc

Original episode published on Nov 6, 2019
⏳ #Aging #Resveratrol #Epigenetics 🧬

About FoundMyFitness: Rhonda Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, and St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California. She has done extensive research on aging, cancer, and nutrition.

It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach.

Learn more about Dr. Rhonda Patrick and her mission for FoundMyFitness at www.foundmyfitness.com

About David Sinclair: David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor. His work on aging has earned him numerous awards for his research, including the Australian Medical Research Medal, and landed him a spot in Time magazine's Top 100 most influential people on the planet. Learn more about David Sinclair at https://sinclair.hms.harvard.e....du/people/david-sinc

Harvard geneticist Dr David Sinclair reveals his complete supplement stack and explains the science behind why taking certain supplements every other day is more effective than taking them daily. He describes how mice given resveratrol every other day lived significantly longer than those given it daily, and why this principle of pulsing applies to metformin, berberine, and other longevity supplements.

He walks through his personal stack including NMN for fuelling the sirtuin enzymes that control aging, resveratrol as the accelerator pedal for those same enzymes, berberine as a natural alternative to the drug metformin, spermidine for stimulating autophagy and slowing epigenetic information loss, glycine for controlling DNA methylation, vitamin D with K2 to keep calcium out of arteries and into bones, and high-dose niacin to lower a dangerous molecule called Lp(a) that most doctors never test for.

Discover:
• Why taking supplements every other day works better than daily
• The full supplement stack a Harvard aging scientist takes himself
• How blind monkeys had their sight restored in six weeks
• The molecule called Lp(a) that is as dangerous as cholesterol and most doctors never test
• Why the single most important thing for longevity is skipping meals
• How sauna bathing is proven to reduce heart disease and early death
• The red light cap that is proven to slow hair loss

📺 Watch the full episode here - https://youtu.be/DnvWAP99r3Y

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Original release date: 11/5/2018

In this episode, David A. Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, provides insight into why we age and how to slow its effects based on his remarkable work on the role of sirtuins and NAD in health and diseases. He also presents the case that stabilizing the epigenetic landscape may be the linchpin in counteracting aging and disease.

We discuss:
-How and why David moved from Australia to Lenny Guarente’s lab at MIT [7:30];
-Sirtuins and aging [15:00];
-A series of experiments elucidating the mechanisms of sirtuins [20:45];
-How are sirtuins activated? [25:30];
-NAD and sirtuin activation [31:00];
-Nicotinamide, sirtuin inhibition, and PNC1 [39:00];
-Resveratrol [43:00];
-The NIH/ITP studies on resveratrol [55:45];
-Does David take any compounds for longevity? [1:00:15];
-NAD precursors (NR, NMN) and pterostilbene [1:02:45];
-Female fertility and NAD precursors [1:14:45];
-A unifying theory of aging [1:20:30];
-Waddington’s epigenetic landscape [1:23:00];
-If David had unlimited resources, what is the experiment he would do? [1:28:25];
-Testing combinations to extend lifespan [1:31:30];
-What made David aware of his mortality at such a young age? [01:33:45];
-What is David’s book going to cover? [01:37:15]; and
-More.

Show notes page: https://peterattiamd.com/davidsinclair/

About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 10 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.

Peter is the founder of Attia Medical, PC, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity. The practice applies nutritional biochemistry, exercise physiology, sleep physiology, techniques to increase distress tolerance, lipidology, pharmacology, and four-system endocrinology to increase lifespan (delaying the onset of chronic disease), while simultaneously improving healthspan (quality of life).

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NMN and NR supplements are taken by millions with the goal of raising NAD+ and slowing aging. This video reviews every major human clinical trial, explains why the animal data is compelling but the human evidence is thin, and gives a realistic picture of who might actually benefit. Full script and sources in the video.

About Me
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Disclaimer: Views are solely those of Dr. Nessim and do not represent any outside organization

Age reversal: David Sinclair's company has dosed the first human with epigenetic reprogramming. The trial is real, it is first-in-human, and its primary endpoint is safety.

On January 15, 2026 the FDA authorized it. On June 9 a patient received an injection into one eye, carrying instructions to partially reset the age of the cells inside it. It is the first time partial epigenetic reprogramming has been tried in a human being.

So what do we actually know? Less than the headlines suggest, and more than you would think.

The trial is ER-100, from Life Biosciences, co-founded by Harvard geneticist David Sinclair. He is the principal in this story, not a commentator on it, and this video says so up front. It enrolls 18 people. It lists 21 primary outcome measures, and every one of them is safety. It is not designed to answer whether age reversal works.

This walks what actually happened, in order: the 2020 Nature mouse result, the primate data, the FDA authorization, the first dose. Then what the registry actually commits to measuring. Then the part worth knowing: why they used 3 of the 4 Yamanaka factors instead of all 4, and why the therapy only runs while the patient takes an antibiotic. The most interesting thing in the first human age-reversal trial is not the reprogramming. It is the off switch.

VERIFICATION: Checked August 5, 2026. NO Phase 1 results have been published. ClinicalTrials.gov NCT07290244 reports has Results = false, status RECRUITING. If that has changed by the time you are watching, this video describes the period before the first readout.

What you'll learn:
• What the FDA actually authorized, and when
• The 2020 Nature result: OSK restores vision in mice
• Why the primate data is solid but unpublished
• 18 patients, 21 primary endpoints, all safety
• Why c-Myc was left out, and what the doxycycline switch does
• How to read any early result: ask what the study was designed to find out

Chapters:
00:00 FDA clears the first age-reversal trial
01:29 The 2020 Nature study that restored vision in mice
04:13 What the ER-100 trial actually is: 18 patients, 21 safety endpoints
06:43 The off switch: 3 Yamanaka factors, not 4
09:26 Evidence tiers: mouse, primate, human safety
11:02 What "age reversal" actually means here
12:49 How to read an early trial result
13:49 A question, not a verdict

SOURCES (all primary, retrieved 2026-08-04):
1. Lu Y, Brommer B, Tian X, ... He Z, Sinclair DA. "Reprogramming to recover youthful epigenetic information and restore vision." Nature 2020;588(7836):124-129. PMID 33268865
2. Nakagawa M, ... Yamanaka S. "Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts." Nature Biotechnology 2008;26:101-106. PMID 18059259
3. ClinicalTrials.gov NCT07290244. Phase 1, ER-100 in optic neuropathies. Estimated enrollment 18. Primary outcomes: safety and tolerability
4. Life Biosciences. FDA clearance of the IND (announced January 28, 2026) and first patient dosed (June 9, 2026)
5. Life Biosciences. Nonhuman primate data presented at the AAO Annual Meeting, Chicago, October 2024. Conference presentation, not peer-reviewed

RELATED:
• Rapamycin and the line one scientist draws: https://youtu.be/li2fhq-tI8A
• Metformin and exercise, what that drug actually does: https://youtu.be/B3FByxo8xH8

Music by Maksim Chubrey from Pixabay: https://pixabay.com/users/cozyvibes-25452378/

Images: David Sinclair and FDA photographs supplied by the channel owner. Laboratory and molecular imagery under the Pixabay Content License.

This video is for general education only and is not medical advice, and it is not a recommendation to take any drug or supplement. The compound discussed may be a prescription medicine; any use for aging or longevity is off-label and not approved for that purpose. No drug is approved anywhere for extending human lifespan. Nothing here is a dose, a protocol, or sourcing guidance. Do not start, stop, or change any medication or supplement without a doctor who knows your health.

From The Longevity Experts. We rank longevity compounds and habits by how strong the evidence actually is, and we say so out loud. No supplement ads, no hype, no fear-mongering, just the honest ranking. Subscribe for evidence-first longevity, ranked.

Download my FREE Nutrition Guide HERE: https://bit.ly/3Jeg9yL

Order MAKE CHANGE THAT LASTS. US & Canada version https://amzn.to/3RyO3SL, UK version https://amzn.to/3Kt5rUK

My guest today is a revolutionary thinker and ground-breaking scientist who’s on a mission to make you younger. He’s Australian biologist and Harvard professor David Sinclair, author of Lifespan: Why We Age – And Why We Don’t Have To. David is one of the world’s leading scientific authorities on longevity, ageing and how to slow its effects.

WATCH THE FULL CONVERSATION:
REVERSE AGING: What To Eat & When To Eat For LONGEVITY | David Sinclair
https://youtu.be/GSkkBkMcwdY

-----
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DISCLAIMER: The content in the podcast and on this webpage is not intended to constitute or be a substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

Taken from JRE #2537 w/David Sinclair
YouTube: https://youtu.be/hxid7FofhMw
JRE on Spotify: https://open.spotify.com/show/....4rOoJ6Egrf8K2IrywzwO

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at https://lifespan.com.

Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.

__________________________________________

In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and pioneer in longevity research – explores the science of eye aging, vision loss, and emerging strategies to preserve vision throughout life.

Dr. Sinclair shares an inside update on ER-100, including his team's successful restoration of vision in non-human primates and the launch of the world's first FDA-cleared age reversal human clinical trial. This Phase 1 clinical trial will evaluate the safety of epigenetic cellular restoration as a therapy.

Additionally, drawing on decades of research, Dr. Sinclair explains why the eyes may offer one of the earliest windows into biological aging, how everyday factors such as sleep position, alcohol consumption, and intraocular pressure influence long-term eye health, and what the latest evidence reveals about nutrition, supplements, and the connection between the eyes and the brain.

00:00 AI & the First Human Clinical Trial to Reverse Aging
08:30 How the Eye Works
16:00 How Light Sets Your Body Clock
20:18 Your Eyes Are Part of Your Brain
21:34 Can Your Eyes Estimate Your Biological Age?
23:43 Can Eye Exams Help Predict Alzheimer's Disease?
24:43 ER-100: Restoring Vision Through Age Reversal
33:17 Why We Lose Vision as We Age
39:32 How to Keep Your Eyes Healthy as You Age
41:53 The Best Foods & Supplements for Eye Health
49:15 Can Diet & Fasting Protect Your Vision?
53:28 Why Violet Light Matters for Eye Health
59:28 Repairing Eye Damage: UV Light, Smoking & Alcohol
03:45 NASA's Space Mice & Swimming Goggles
05:59 Are You Genetically Predisposed to Eye Disease?
07:48 What's Next in Age Reversal Research?
__________________________________________

Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.

Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).

If you’d like to learn more or try these tools:

○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN

○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN

○ Withings: Get 10% off smart health devices at https://withings.com/LIFESPAN
__________________________________________
Legal & Medical Disclaimers

The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.

The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.

Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.

From time to time, Lifespan may discuss or partner with third-party products or services. Third party references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.

Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.

The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

ER-100 is the world’s first age reversal therapy to enter FDA-cleared human clinical trials, and earlier this year the first participant received the first dose - a special moment that Dr. David Sinclair witnessed firsthand:

“It was really emotional after 30 years of research to finally see it entering human trials. And I'm happy to report that the trial is going well, and I'll continue to report how the trial is going.

To see a concept that we pioneered in mice and monkeys finally being put into human beings made me extremely proud of the work my teams and my colleagues have done.”

If aging is, in part, a loss of biological information, then restoring that information could help cells remember how to function like they're young again. This is the idea behind ER-100 (or “Epigenetic Reprogramming 100”), a cellular rejuvenation therapy that uses epigenetic reprogramming to try and help damaged retinal nerve cells recover more youthful function.

Watch the full episode to learn more about ER-100, longevity, the science of eye health and vision optimization, and how you can apply these in your own life to improve your health.

New Lifespan Episode 4: “Inside the World’s First Age Reversal Trial” - available now on YouTube, Spotify, and Apple Podcasts.

Join us at Lifespan.com, where we're building the world's largest longevity community to help you and your loved ones live your longest, healthiest lives.

The FDA just cleared a clinical trial that could mark a major turning point in the science of aging.
At the 2026 World Governments Summit, David Sinclair discussed the possibility of reversing aspects of biological aging and explained how scientists are moving from laboratory research toward human clinical testing. �

World Governments Summit
The breakthrough involves epigenetic reprogramming — an approach designed to restore older or damaged cells toward a younger, more functional state without changing the underlying DNA sequence.
In January 2026, the U.S. FDA cleared the Investigational New Drug (IND) application for ER-100, developed by Life Biosciences. The Phase 1 trial is studying the therapy in patients with optic neuropathies, including open-angle glaucoma and NAION.

Then, in June 2026, Life Biosciences announced that the first participant had been dosed in the Phase 1 ER-100 clinical trial. The study is primarily evaluating safety and tolerability, while also assessing measures of visual function.


ER-100 uses controlled expression of three transcription factors — OCT4, SOX2 and KLF4 (OSK) — as part of Life Biosciences' epigenetic restoration approach. The goal is to restore cellular function by resetting aspects of the epigenetic state toward more youthful patterns.

But there is an important distinction:
Scientists have NOT proven that they can reverse human aging yet.
This is an early Phase 1 clinical trial. The results will have to show whether the approach is safe and whether the biological effects seen in preclinical research can translate into meaningful benefits in humans.
In this video, we look at what David Sinclair explains about the breakthrough, what scientists have actually achieved, how epigenetic reprogramming works, why the FDA clearance matters, and what the first human trial could mean for the future of aging research.

Could this be the beginning of a new era in medicine — where scientists don't just treat diseases of aging, but target the biology of aging itself?
We'll break down the science, the clinical trial, the evidence, and the questions that remain unanswered.

This video is for educational and informational purposes. The therapies discussed are investigational and are not approved treatments for reversing aging.


#ReverseAging #Aging #DavidSinclair #Longevity #AntiAging #AgingResearch #Epigenetics #LongevityScience #LifeExtension #Biotechnology #ScienceNews #HumanTrial

Get Real checks the claims from The Joe Rogan Experience #2537 with David Sinclair - one at a time, against the published record. Every claim is played in full from the episode before we check it.

11 claims audited against 167 sources.
4 SOLID | 4 NEEDS CONTEXT | 3 FALSE

CHAPTERS
0:00 What this is
0:32 Regrowing a severed optic nerve - SOLID
2:33 Five habits, fifteen years - SOLID, but not from the study he named
3:55 The Waldinger study - NEEDS CONTEXT
5:54 The Israeli hyperbaric trial - NEEDS CONTEXT
8:21 "You can get away with very little sleep" - FALSE
10:41 Vascular dementia - half right, half wrong
13:01 The billionaire longevity companies - NEEDS CONTEXT
14:51 150,000 deaths a day - NEEDS CONTEXT
16:53 The DRD4 document shown on screen - SOLID
19:08 The verdict

THE VERDICTS AND WHERE THEY COME FROM

SOLID - The 2020 Nature paper regrew severed optic nerves in mice.
Lu Y. et al., "Reprogramming to recover youthful epigenetic information and restore vision," Nature, December 2020. OSK delivered by AAV into retinal ganglion cells. Demonstrated in mice, not humans.

SOLID - Five habits are worth roughly fifteen years.
Li Y., Hu F.B., et al., Circulation, July 2018. 78,865 women and 44,354 men; gain at age 50 of 12-14 years.

FALSE - ...but they come from the Waldinger study, and one of them is no alcohol.
The fifteen years comes from the Circulation paper, not from Waldinger. That paper's alcohol factor is MODERATE drinking, not abstention.

NEEDS CONTEXT - The Waldinger study ran 40 years on World War II vets.
The Harvard Study of Adult Development began in 1938 and has run 85+ years. Waldinger is its fourth director. Two cohorts: Harvard undergraduates and inner-city Boston boys. Its headline finding - relationships - is his.

NEEDS CONTEXT - The Israeli hyperbaric trial reversed aging.
Hachmo et al., Aging (Albany NY), 2020. 35 participants, NO control group, and the outcome measured was telomere length in isolated blood cells - a surrogate marker, not a health outcome. From the paper's own competing interests statement: "AH, BY, ZY work for AVIV Scientific LTD. ES is a shareholder at AVIV Scientific LTD."

FALSE - You can get away with very little sleep if it is deep sleep.
Kwok et al., JAHA 2018 - 74 cohorts, 3.3 million participants; mortality and cardiovascular risk rise as sleep falls below 7 hours. The glymphatic mechanism he calls settled is contested: Xie/Nedergaard, Science 2013 found clearance rises during sleep; Miao, Franks and Wisden, Nature Neuroscience, June 2024 found it falls.

SOLID - Vascular dementia is the second leading cause of dementia.
15-20% of diagnosed cases. Cleveland Clinic; Alzheimers.gov / NIH.

FALSE - ...and it is the easiest to reverse.
Vascular dementia involves infarction - brain tissue that has already died. No intervention reverses it. The RISK FACTORS are modifiable; the damage is not. Vascular dementia review, PMC 2025.

NEEDS CONTEXT - Bezos, Altman and Armstrong started rival companies, all with billions.
Altos Labs (Bezos) launched January 2022 with $3B. NewLimit (Armstrong) has raised roughly $755M. Retro Biosciences (Altman) operates with $180M. He also called it "Altos Pharma."

NEEDS CONTEXT - 150,000 people die every day of aging.
Andrew Steele, "Deaths caused by ageing," 2026: 105,900 of about 150,800 daily deaths worldwide are attributable to aging - roughly 70%. 150,000 is closer to the all-causes total.

SOLID - The DRD4 7R document read out on air.
Ding, Moyzis et al., American Journal of Human Genetics, 2004; Goeren, 2014. Roughly 48% across the Americas, about 2% in East Asia. We check the document, not the person - it was an AI search result read aloud on the show.

HOW WE SCORE
SOLID - the published record backs it.
NEEDS CONTEXT - true as far as it goes, but the framing is off.
UNSUPPORTED - no evidence either way. This is not an accusation.
FALSE - the published record contradicts it.

Two further claims - US glaucoma prevalence, and whether GLP-1 drugs double the risk of NAION - are held for a follow-up. The NAION literature disagrees with itself across four studies and deserves its own episode.

A NOTE ON HOW THIS IS MADE
The narration voice and most of the imagery in this video are AI-generated. The generated imagery carries mood only - never a citation, date, figure or document. Every fact you read on screen is on a source card built from the literature listed above. We are not doctors and this is not medical advice; we report what the published record says.

Original episode: The Joe Rogan Experience #2537 with David Sinclair.

#JoeRogan #DavidSinclair #FactCheck #Longevity #JRE

In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed.

#DavidSinclair #Longevity #Lifespan

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Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com

Timestamps:
00:00:00 Kicking Off Episode Five: Interventions on the Cutting Edge
00:02:39 Expressing Gratitude to the Sponsors
00:05:28 Testosterone Replacement Therapy
00:10:09 Human Growth Hormone
00:13:56 Peptide Supplementation and Regenerative Signaling
00:18:11 MOTS-c, Humanin, and Other Peptides
00:25:05 Exosome Therapy
00:31:56 A Primer on Stem Cells and Yamanaka Factors
00:37:59 Stem Cell Aging and Cord Blood Banking
00:41:42 The Therapeutic Potential of Stem Cells
00:43:37 Cellular Reprogramming
00:51:35 Resetting the Aging Clock
00:56:50 The Future Looks Bright
00:58:15 Next Week’s Episode: External Aging
00:58:36 Subscription and Support Options

Links:
Benefits and risks of testosterone treatment: https://bit.ly/35I3uTs
Eunuchs are long-lived: https://bit.ly/3ukL1GU
Longevity is enhanced in mice lacking growth hormone: https://go.nature.com/3AOTW4k
MOTS-c and age-dependent physical decline in mice: https://go.nature.com/34aUgi6
Fatty liver disease, obesity, and an analog of MOTS-C: https://bit.ly/3Ho7GFE
Humanin regulates lifespan and healthspan in mice: https://bit.ly/3Gy0lm1
Humanin ameliorates diabetes in mice: https://bit.ly/3ukiFw7
Mouse aging can be modulated via exosomes: https://go.nature.com/3oi0sM4
Exosomes and ulcer healing in older mice: https://bit.ly/3oEhPaf
Generating induced pluripotent stem cells: https://bit.ly/3APMypv
Vision loss after ocular injections: https://bit.ly/3L2yVIh
Mesenchymal stem cells and human frailty: https://bit.ly/3s6kzxX
Restoring vision loss in older mice: https://go.nature.com/335iysI
Reversing epigenetic age in humans: https://bit.ly/342XXGJ

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

Welcome to Impact Theory with Tom Bilyeu. In today's episode, we sit down with legendary Harvard longevity scientist David Sinclair for a conversation that could genuinely change how you think about aging, disease, and the human body's potential for self-renewal.

Tom and David dive deep into one of the most controversial and exciting frontiers in modern science — the possibility of not just slowing aging, but actually reversing it at the cellular level. They unpack the Alzheimer's puzzle: why amyloid plaque may not be the true villain, what's actually happening in aging brain cells, and why David's lab is seeing memory improvements in animals without clearing any plaque at all.

Then the conversation takes a stunning turn into nerve regeneration. David shares the Nature cover-worthy experiment where his lab didn't just slow nerve degeneration — they regrew crushed optic nerves to 100%, a feat other labs had only achieved at 5%. The implications stretch far beyond vision: spinal injuries, ALS, age-related balance loss, and beyond. The science isn't just theoretical — it's already working in monkeys.

But perhaps most immediately relevant to everyday people is David's work on a consumer-grade age reversal product — something that could be a supplement, a drink, or a topical cream — backed by the same mechanisms driving his lab's most advanced research. After just four weeks in mouse models, the results across 20 different tests of strength, memory, and balance were undeniable.
They also get candid about the risks: the cancer concern, the gap between bench and bedside, the regulatory bottlenecks keeping breakthrough therapies out of reach, and why David refuses to rush anything that isn't clinically proven. This is the science of getting younger — and it's closer than you think.

🔔 Subscribe so you never miss an episode. Tom goes live Monday, Wednesday, and Friday at 7AM Pacific only on @TomBilyeu!

Link to Interview: https://youtu.be/tMYoiHSYgWw

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David Sinclair, aging reversal, longevity science, Harvard longevity, Alzheimer's research, amyloid plaque, nerve regeneration, optic nerve regrowth, ALS treatment, spinal cord injury, age reversal supplement, anti-aging pill, gray hair reversal, skin rejuvenation, epigenetic reprogramming, longevity podcast, Tom Bilyeu, Impact Theory, live longer, biological age

Taken from JRE #1670 w/David Sinclair:
https://open.spotify.com/episode/55UlxYWPfV46f7puMkZPeD?si=WBxKap8wSb-hUv-dV7Q2ig&dl_branch=1

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In this video, Dr. David Sinclair explains why he quit dairy and adopted a more Mediterranean diet. How does daily impact other systems in the body? Is too much meat really all that bad for you?

Watch the full interview with David Sinclair here: https://youtu.be/RRdTfh1_88I

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What are the best fruits for longevity, low sugar, and long-term metabolic health? In this video, we explore the Top 3 “FRUITS” Dr. David Sinclair recommends for healthy aging avocado, blueberries, and cantaloupe.

Dr. Sinclair, a Harvard longevity researcher, emphasizes choosing fruits not for sweetness, but for their polyphenols, antioxidants, fiber, and healthy fats that support mitochondria, metabolic health, and cellular defense pathways.

You’ll learn:
• Why avocado is one of Sinclair’s top longevity foods
• How oleic acid may support cellular resilience and aging defenses
• Why blueberries and dark berries are rich in polyphenols
• Why cantaloupe offers great nutrition with lower sugar impact
• How these fruits support heart, brain, and metabolic health


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Copyright disclaimer under section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use.

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Welcome to Lifespan with Dr. David Sinclair.

Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research.

Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. New episodes will be released every Wednesday morning of both January and February 2022.

This podcast can also be found on all podcast platforms, including Apple Podcasts and Spotify: https://lifespanpodcast.com/

My goal in creating this podcast is to discuss the science behind why we age and to share the newest research on what we can do to slow, stop and even reverse aging. In doing so, I hope to help explain the science in an easy-to-understand manner and I hope to help all our listeners in their journey to be healthier at any stage of life.

Upcoming episodes will cover: why aging is a disease, the impact of dietary choices, fasting and exercise on aging, how various supplements and prescription drugs can protect against aging, why cosmetic aging occurs and how to combat it, the benefits and advancements of biotracking, and the future of age reversal.

Please subscribe, share with friends, leave a comment or review, and most of all, thank you for coming with us on this journey into the mechanisms of aging and exploration of the tools for living longer, healthier lives!

#Lifespan #DavidSinclair #Aging

Please note that this podcast is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice.

Is aging a disease that can be cured? Neil deGrasse Tyson and cohosts Chuck Nice and Gary O’Reilly discover the field of epigenetics, the Information Theory of Aging, and curing blindness for mice with Professor of Genetics at Harvard Medical School, David Sinclair.

What is epigenetics? Discover the difference between genetics and epigenetics. We discuss whether aging is a disease and if there have been any changes in aging throughout the centuries. David breaks down the information theory of aging and how epigenetic inheritance works. Plus, Chuck tells us about some of the studies he’s reading and how behaviors during your lifetime can be epigenetically passed onto your children.

Could we someday cure death? What does aging look like in the broader animal kingdom? We look at aging from an evolutionary standpoint, restoring vision in blind mice, and what the length of your telomeres tells you. We break down conflicting information regarding diet and how to not just live longer but live younger, longer. What are the genes that control aging?

We break down what anti-aging medicine would look like and whether it would be affordable for everyday people. Learn about the world's oldest mice with the youngest eyes. We discuss the Yamanaka genes and how they can be utilized to turn back time on a cellular level. Is DNA destiny?

Thanks to our Patrons Jason L, Daniel Holzmann, Anne P Vance, Unknown, Myles G Blanton, Paul A. Straus, and Gregory Dees for supporting us this week.

NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free.

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00:00 - Introduction - David Sinclair
02:28 - What Are Epigenetics?
5:03 - Is Aging A Disease?
7:33 - Information Theory of Aging
9:31 - Epigenetic Inheritance
15:23 - Do Some People Age Differently?
16:56 - Could We Never Die?
21:13 - Is DNA Our Destiny?
22:23 - Aging in the Animal Kingdom
24:30 - Curing Blindness
27:29 - Telomere Length, OSK Therapy, & The Hallmarks of Aging
30:35 - StarTalk Patreon
32:18 - Can You Cure Aging?
34:25 - Neil Wants Immortal Mice
36:58 - Using AI for Gene Therapy
38:17 - NAD & Yamanaka Genes
40:48 - Biological Stress & Lifestyle Effects on Aging
45:23 - Closing Thoughts

David Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects.
https://genetics.med.harvard.e....du/sinclair/people/s

✎ Get free access to our vault of PDF summaries for every YouTube video here: https://believe.evancarmichael.com/the-vault

✎ Want to live longer, feel better, and unlock your full potential? In today’s episode, we dive into David Sinclair’s top rules for longevity—covering everything from intermittent fasting, eating the right foods, and optimizing your body’s natural defenses against aging. Sinclair shares groundbreaking insights from his research, including studies on calorie restriction, metabolic health, and how eating less often can activate longevity genes. If you’re serious about extending your lifespan and improving your health, you don’t want to miss this!

One of the biggest takeaways? What you eat is important, but when you eat might be even more crucial. Sinclair explains how fasting triggers hormesis, a biological response that strengthens the body and fights aging. He also dives into the importance of omega-3 fatty acids, reducing glucose intake, and incorporating plant-based foods for better longevity. Plus, we get into the power of movement, exercise, and sleep—all key factors in slowing down the aging process and keeping your body in peak condition.

So, are you ready to take control of your health and future? Whether it’s resetting your biological clock, understanding how metabolism affects aging, or learning how simple lifestyle changes can add years to your life, this episode is packed with insights to help you become your healthiest, most vibrant self. What’s your biggest takeaway from David Sinclair’s advice? Drop a comment below and let’s talk about it! Continue to believe, and I’ll see you tomorrow for another shot of #Entspresso!

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★ RECOMMENDED VIDEOS FOR YOU ★
If you liked this video, you'll love these ones:
• THESE are the Simple STEPS to HEAL Your BODY and Live LONGER! | Dr. Alan Goldhamer | Top 10 Rules - https://youtu.be/g5LCrAH-cfs
• WEIGHT LOSS Strategies Based on SCIENCE That Actually WORK! | Dr. Jason Fung | Top 10 Rules - https://youtu.be/hYQnGT9hf54
• Do THIS First Thing in the MORNING to Activate the LAW of ATTRACTION! | John Assaraf | Top 10 Rules - https://youtu.be/Ua_1xpcdTUQ

✔ SOURCES ✔
https://youtu.be/wD8reCw3Kls David Sinclair
https://youtu.be/vVGMRDYMcZ8 Chris Williamson
https://youtu.be/4Yc5EXX9YWg David Sinclair
https://youtu.be/mmRzeD4_41M Lex Clips
https://youtu.be/1NaQv2_Z_Fk Ed Mylett
https://youtu.be/1qofuBMQRu0 Reverse Aging Revolution
https://youtu.be/RUiRFGX1Oqs David Sinclair
https://youtu.be/-6Laa2LiS2E David Sinclair
https://youtu.be/X1kLizzdb2c David Sinclair

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#Believe

Can we really cure ageing? David Sinclair thinks so, and he's going to try to prove it.

David Sinclair is a scientist and entrepreneur working on increasing human health, productivity, and lifespan. After co-discovering a molecular cause of aging at the Massachusetts Institute in Boston in the mid-1990s, he joined the faculty of Harvard Medical School where he is now a tenured Professor. In 2005, he founded the Glenn Laboratories for Aging Research at Harvard and serves as their Co-Director. He is also a Professor at the Lowy Cancer Centre at the University of New South Wales, Sydney.

His research is aimed at understanding why we grow old and using this knowledge to prevent and treat both rare and common diseases. He is perhaps best known for identifying resveratrol from red wine as an anti-aging molecule. He has founded four biotechnology companies; to treat age-related diseases (Sirtris), improve female reproductive health and IVF (OvaScience), treat type 2 diabetes (Cohbar), and develop vaccines against malaria, chlamydia, tuberculosis, pneumonia, and cancer (Genocea).

In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)

This episode was filmed at the 2026 Abundance360 Summit. Learn more at https://www.abundance360.com/

In this insightful interview, Dr. David Sinclair discusses groundbreaking advancements in longevity research, including epigenetic reprogramming trials, the potential for extending human lifespan, and accessible therapies. He shares his personal protocols and the future of anti-aging science, emphasizing the importance of innovation and community support.

Get access to metatrends 10+ years before anyone else - https://qr.diamandis.com/metatrends

David A. Sinclair, A.O., Ph.D., is a tenured Professor of Genetics at Harvard Medical School and a serial biotech entrepreneur.

Peter H. Diamandis, MD, is the Founder of XPRIZE, Singularity University, ZeroG, and A360

Chapters:
00:00 - The Dawn of Epigenetic Reprogramming
02:44 - Exploring the Potential of Longevity Therapeutics
05:26 - Innovations in Gene Therapy and Accessibility
07:56 - The Future of Longevity: Cost and Accessibility
10:44 - The Science of Aging: Limits and Possibilities
13:01 - Funding Science: A New Approach to Research
15:49 - Personal Longevity Protocols and Lifestyle Choices

–

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Apply to Dave's and my new fund: https://qr.diamandis.com/linkventureslanding

Go to Blitzy to book a free demo and start building today: https://qr.diamandis.com/blitzy

Your body is incredibly good at hiding disease. Schedule a call with Fountain Life to add healthy decades to your life, and to learn more about their Memberships: https://www.fountainlife.com/peter

_

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Listen to MOONSHOTS:

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–
*Recorded on March 9th, 2026
*The views expressed by me and all guests are personal opinions and do not constitute Financial, Medical, or Legal advice.

In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels.

#Exercise #DavidSinclair #Longevity

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Dr. David Sinclair Social:
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Twitter - https://twitter.com/davidasinclair
Facebook - https://www.facebook.com/davidsinclairphd

Matthew LaPlante's Social:
Twitter - https://twitter.com/mdlaplante

Timestamps:
00:00:00 Introducing Episode Three: Exercise Hot Cold
00:01:01 A Pernicious Element Called Iron (Fe)
00:02:46 A Quick Primer on Free Radicals
00:05:42 Review of Dietary Takeaways
00:07:01 Acknowledging the Sponsors
00:09:32 Biological Adversity and the Survival Circuit
00:13:24 Survival Sensors (i.e., mTOR, AMPK, and Sirtuins) and Communicators (e.g., Insulin)
00:17:25 Get Off Your Butt
00:19:40 Exercise Protects against Disease and Mortality
00:21:17 Daily Step Count and Walking After Eating
00:22:33 Exercise Activates AMPK and Creates More Mitochondria
00:24:03 Vigorous Exercise, Hypoxia, and the Electron Transport Chain
00:28:19 Exercise Increases Glucose Sensitivity and Stimulates Blood Vessel Formation
00:32:13 The Epigenome and Biological Age are Impacted by Exercise
00:36:43 How to Measure your Biological Age
00:37:31 Exercise Recommendations
00:39:28 Wearables and Individualized Health Tracking
00:43:14 The Importance of Weight Training
00:46:08 Physical Activity and Senescent Cells
00:48:01 Exercise Wrap-up and Takeaways
00:49:47 Hyperbaric Oxygen Therapy (HBOT)
00:57:24 Cold Therapy
01:03:50 Applying Heat
01:07:04 Adversity Mimetics Produce Endorphins
01:08:07 A Basic Protocol for Mimicking Adversity
01:10:04 Next Week’s Episode: Molecules and Supplements
01:10:45 Options for Subscription and Support

Links:
A single mutation doubles lifespan in worms: https://go.nature.com/33QhCsV
Extending lifespan in yeast with one mutation: https://bit.ly/3FSDf9n
Daily step count and health outcomes: https://bit.ly/3ruVlsD
Reversing vascular aging in mice: https://bit.ly/3rwCYDz
Aerobic exercise is linked to a lower biological age: https://bit.ly/33pQTUf
A lifestyle and diet intervention decreases biological age: https://bit.ly/3fzyuqi
An epigenetic clock that predicts time-to-death: https://bit.ly/3rz4yAp
Ultra-cheap age prediction: https://bit.ly/3nFeTto
Exercise decreases biomarkers of cellular senescence: https://bit.ly/3AbYSQC
Telomere length is increased by hyperbaric oxygen therapy: https://bit.ly/3Aff57x
Hyperbaric oxygen therapy improves cognitive performance: https://bit.ly/3GGCzoL
A cold temperature promotes longevity in worms: https://bit.ly/3FHy7om
Sauna bathing, mortality, and cardiovascular risk: https://bit.ly/33P09RC

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

See Andrew Huberman live in New York, Los Angeles & San Francisco:
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In this ⁠Huberman Lab Essentials⁠ episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging.

We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse key aspects of biological aging.

Episode show notes: https://go.hubermanlab.com/MW6SYCf

Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: https://youtu.be/n9IxomBusuw

Watch more Huberman Lab Essentials episodes: https://youtube.com/playlist?l....ist=PLPNW_gerXa4OGNy

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*Timestamps*
00:00:00 David Sinclair
00:00:20 Longevity, Anti-Aging, Aging as a Disease
00:02:27 Causes of Aging; Epigenome & Genes
00:04:53 CD & Scratches Analogy, DNA, Silencing & Expressing Genes
00:06:44 Physical Appearance & Aging
00:07:36 Childhood Development & Aging, Horvath Clock, Accelerate Aging
00:10:13 Rates of Puberty & Aging, Growth Hormone
00:11:20 Body Size & Longevity; Epigenetics
00:11:50 Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose
00:15:14 Tool: Skip a Meal
00:15:50 Longer Fasts & Autophagy, “Deep Cleanse”; Fluids, Electrolytes
00:17:28 Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors
00:21:37 Breaking a Fast, Tools: Do Your Best; Transitions
00:24:13 Sirtuins, NAD, NMN Supplementation
00:26:18 Iron & Senescent Cells; Personalize Medicine
00:27:48 Tool: Blood Markers, CRP
00:29:57 Tool: Aerobic & Resistance Exercise
00:31:02 Estrogen, Fasting & Fertility; Aging & Rejuvenation
00:33:28 Acknowledgements

Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

We might be the first generation that gets to live forever. Because Dr. David Sinclair, a Harvard geneticist just cracked the code to living forever. His lab reversed biological age by 75% in just six weeks. And now the FDA has officially approved the very first human aging reversal trial in history. But it's not just one scientist. The world's billionaires are investing billions into the same science. The Holy Grail of science is real. And it begins right now.

In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered.

#DavidSinclair #Longevity #Aging

Thank you to our sponsors:
Levels - https://levels.link/sinclair
Athletic Greens - https://athleticgreens.com/sinclair
InsideTracker - https://insidetracker.com/sinclair

Our Patreon page:
https://www.patreon.com/davidsinclair

Lifespan book:
https://amzn.to/3sUqurT

Lifespan podcast website: https://www.lifespanpodcast.com

Dr. David Sinclair Social:
Instagram - https://www.instagram.com/davidsinclairphd
Twitter - https://twitter.com/davidasinclair
Facebook - https://www.facebook.com/davidsinclairphd

Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com

Matthew LaPlante's Social:
Twitter - https://twitter.com/mdlaplante

Timestamps:
00:00:00 Introducing Episode Eight: The Future of Anti-aging Medicine
00:03:49 Thanking the Sponsors
00:06:48 Modern Healthcare, Disease Detection, and Circulating DNA
00:11:30 Wearable Monitors: A Dashboard for your Body
00:20:31 Types of Health Sensors
00:24:20 Big Data, Privacy, and Criminal Investigation
00:30:16 Cutting-edge Testing and Biological Age
00:36:40 Using Personalized Data to Inform your Diet
00:41:48 Optimizing Exercise and Activity-mimetics
00:45:02 Resetting the Aging Clock
00:53:45 Repeatable Age Reversal and Safety
00:56:11 Longer Life, Population Size, and Economics
01:00:18 Skillbatical
01:03:06 Putting in the Work for Longevity
01:04:56 Thanking the Podcast Team and Wrapping Up Season One
01:08:27 Options for Subscription and Support

Links:
Affordable epigenetic age prediction: https://bit.ly/3nFeTto
Waitlist for a new biological age company: https://www.tallyhealth.com
Pharmacologically reversing age in humans: https://bit.ly/342XXGJ
Restoring vision in mice via reprogramming: https://go.nature.com/335iysI
Targeting aging is economically valuable: https://go.nature.com/3IgrQ4Z

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

Harvard geneticist David Sinclair returns to explain how his lab's age-reversal technology has moved from mice and primates into FDA-cleared human trials — starting with an attempt to reverse vision loss from glaucoma, a condition considered permanent. Sinclair breaks down the science of Yamanaka factors, why using three genes instead of four sidesteps the cancer risk, and his core thesis: make the body young enough and it can cure its own diseases.

He and James also go deep on the practical longevity playbook: NMN, NAD and Sirtuins, metformin and berberine, testosterone and muscle mass, sleep, diet, and how to separate real science from longevity misinformation. Sinclair shares his own protocol at 56, his 86-year-old father's results, and teases a next-generation "rejuvenation in a pill" molecule his lab hopes to test in humans.

Note: Sinclair discusses early-stage, in-trial, and animal-model research. His forward-looking claims are his own and are not yet proven in humans. Nothing here is medical advice — talk to a physician before changing any supplement or medication.

In this episode:
1. How age-reversal tech reached FDA-cleared human trials, starting with the eye
2. What Yamanaka factors are and why they act as a "factory reset" for cells
3. Why three genes (OSK) reverse aging ~75% without triggering cancer
4. The built-in antibiotic "on/off" safety switch behind the therapy
5. Why reversing the age of tissue may let the body cure disease at its source
6. The realistic timeline, cost problem, and path from eye injections to a pill
7. Sinclair's take on NMN, NAD, metformin, berberine, testosterone, and sleep
8. What's next after glaucoma: liver, joints, skin, and a next-gen molecule

Timestamps:
0:00 – Aging as a disease we could cure
2:00 – Reversing aging in the eye to treat glaucoma (FDA cleared)
3:00 – Yamanaka factors and why three genes beat four
6:00 – The breakthrough: ~75% age reversal, safely
11:00 – Make the body young enough and it cures itself
14:00 – Phase 1 safety and the path to approval
19:00 – The cost problem and realistic timeline
23:00 – NMN, NAD and sirtuins: the information theory of aging
28:00 – Cutting through longevity misinformation
30:00 – Testosterone, muscle mass, diet and sleep
40:00 – What comes after glaucoma, and a rejuvenation pill
44:00 – Sinclair's new Lifespan podcast and foundation

About Lifespan:
Dr. David Sinclair founded Lifespan to make the latest longevity science more accessible and help everyone live their longest, healthiest lives.
He's now building Lifespan, the world's largest community dedicated to extending human longevity well beyond today’s limits. Join early access at https://www.lifespan.com.

New Season 2 episodes of Lifespan with Dr. David Sinclair -- the #1 health and wellness podcast -- are now available on YouTube, Spotify, and Apple Podcasts.

Subscribe here: https://www.youtube.com/c/JamesAltucherShow/
More on Episodes on Longevity here: https://youtube.com/playlist?list=PLUHxxj4ce298&si=6qsDxZBzSo1JnbIV

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altucher@gmail.com

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The Harvard geneticist sold a fake miracle pill to GlaxoSmithKline for $720,000,000, and now wants the world to believe that he has discovered a new immortality molecule.

Everyone wants to live a long and healthy life. No one wants to die. The oldest scam in history is the longevity lie. The first writing recorded on Sumerian clay tablets recounts the story of Gilgamesh’s failed quest to bring his friend back from the dead. The immutable fact of mortality has dogged human kind since its very beginning. And yet every age has brought with it its own crop of magicians, alchemists and scientists promising eternal life. Their pitch is always the same: everyone who came before them was a charlatan, but they have the secret sauce.

The most famous longevity grifter of our age is no different. If you’ve ever heard a news story that a glass of red wine might make you live longer, it was because of his groundbreaking research. Harvard geneticist David Sinclair is one of the most decorated scientists on the planet. He’s listed as an author on more than 500 papers, his work has been cited more than 96,000 times and he holds 50 patents. He was the editor of the journal Aging.

Resume aside, David Sinclair is no different than any other health grifter throughout the ages, and great fortunes have been squandered in pursuit of his “science.” In this week’s video I dive into his 25 year history of scientific mistakes, lies and fraud. I show how he used disproven research on the chemical “resveratrol” to sell a best selling book and, ultimately, a company to the pharmaceutical drug maker GlaxoSmithKlein for $720,000,000. Two years after the sale, the research was proven to not work, and Sinclair became one of the richest scientists in America. Now, ten years after that work fell apart, Sinclair is at it again selling the idea of a new immortality molecule called NMN.

This video took me three weeks to put together, but it was worth the wait.

CORRECTIONS: Robert Sclafani, Ph.D. is a professor emeritus at University of Colorado School of Medicine in Aurora, not CU-Boulder as stated in this video. Additionally, his meeting with David Sinclair and the member of the Nobel Prize committee occurred in Colorado, not Europe. More about Sclafani here: https://medschool.cuanschutz.e....du/biochemistry/peop

Additional Resources:
@DrBradStanfield "The David Sinclair $720 Million Train Wreck!": https://www.youtube.com/watch?v=Xn0EJQPyxkA

@HealthnewsOfficial "David Sinclair EXPOSED: REAL Truth Behind His Controversial Claims" https://www.youtube.com/watch?v=6I5KQGPwHjg


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#longevity #davidsinclair #harvard

©PokeyBear LLC (2024)

See Andrew Huberman live in New York, Los Angeles & San Francisco:
https://go.hubermanlab.com/protocols-event

In this episode, I am joined by Dr. David Sinclair, tenured professor of genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To and the host of the Lifespan podcast, which launches January 5, 2022.

In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the process. We cover fasting and supplementation with resveratrol, NAD, metformin and NMN. We also explore the use of caffeine, exercise, cold exposure and why excessive iron load is harmful. Further topics include food choices for offsetting aging and promoting autophagy (clearance of dead cells) and the key blood markers everyone should monitor to determine biological versus chronological age. We look ahead to the future of longevity research and technology.

This episode includes extensive basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it.

For an up-to-date list of our current sponsors, please visit our website: https://www.hubermanlab.com/sponsors. Previous sponsors mentioned in this podcast episode may no longer be affiliated with us.

Dr. David Sinclair Links:
Lifespan Podcast: https://lifespanpodcast.com
Twitter: https://twitter.com/davidasinclair
Instagram: https://www.instagram.com/davidsinclairphd/
YouTube: https://www.youtube.com/davidsinclairpodcast
Lifespan (book): https://amzn.to/47MLimC
Aging Test Waitlist: https://www.tallyhealth.com
Harvard Lab Website: https://sinclair.hms.harvard.edu

Social:
Instagram - https://www.instagram.com/hubermanlab
Twitter - https://twitter.com/hubermanlab
Facebook - https://www.facebook.com/hubermanlab
Website - https://hubermanlab.com
Newsletter - https://hubermanlab.com/neural-network

Timestamps:
00:00:00 Dr. David Sinclair, Harvard Medical School
00:03:30 ROKA, InsideTracker, Magic Spoon
00:07:45 “Aging as a Disease” vs. Longevity & Anti-Aging
00:10:23 What Causes Aging? The Epigenome
00:15:53 Cosmetic Aging
00:17:15 Development Never Stops, Horvath Clock
00:20:12 Puberty Rate as a Determinant of Aging Rate
00:23:00 Fasting, Hunger & Food Choices
00:32:44 Fasting Schedules, Long Fasts, (Macro)Autophagy
00:34:50 Caffeine, Electrolytes
00:35:56 Blood Glucose & the Sirtuins; mTOR
00:37:55 Amino Acids: Leucine, “Pulsing”
00:44:35 Metformin, Berberine
00:50:29 Resveratrol, Wine
00:53:20 What Breaks a Fast?
00:56:45 Resveratrol, NAD, NMN, NR; Dosage, Timing
01:09:10 Are Artificial Sweeteners Bad for Us?
01:12:04 Iron Load & Aging
01:15:05 Blood Work Analysis
01:19:37 C-Reactive Protein, Cholesterol: Serum & Dietary
01:26:02 Amino Acids, Plants, Antioxidants
01:33:45 Behaviors That Extend Lifespan, Testosterone, Estrogen
01:40:35 Neuroplasticity & Neural Repair
01:46:19 Ice Baths, Cold Showers, “Metabolic Winter”
01:48:07 Obesity & How It Accelerates Aging, GnRH
01:52:10 Methylation, Methylene Blue, Cigarettes
01:56:17 X-Rays
01:59:00 Public Science Education, Personal Health
02:05:40 The Sinclair Test You Can Take: www.doctorsinclair.com
02:08:13 Zero-Cost Support & Resources, Sponsors, Patreon, Supplements, Instagram

The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.

#DavidSinclair #Longevity #BrainHealth

Thank you to our sponsors:
Athletic Greens - https://athleticgreens.com/sinclair
InsideTracker - https://insidetracker.com/sinclair
Levels - https://levels.link/sinclair

Our Patreon page:
https://www.patreon.com/davidsinclair

Lifespan book:
https://amzn.to/3sUqurT

Lifespan podcast website: https://www.lifespanpodcast.com

Dr. David Sinclair Social:
Instagram - https://www.instagram.com/davidsinclairphd
Twitter - https://twitter.com/davidasinclair
Facebook - https://www.facebook.com/davidsinclairphd

Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com

Matthew LaPlante's Social:
Twitter - https://twitter.com/mdlaplante

Timestamps:
00:00:00 Introducing Episode Seven: Aging of the Brain
00:04:39 Thanking the Sponsors
00:07:38 Ex-differentiation as a Driver of Aging
00:09:22 The Brain Ages Slowly
00:14:17 Cognitive Function and Plasticity
00:17:44 Three Longevity Pathways: mTOR, AMPK, and Sirtuins
00:23:26 Plant-based Diets and B-vitamins
00:28:32 Homocysteine, Plaque, and Vasculature
00:32:35 Fatty Acids
00:35:48 Physical Activity
00:39:14 Metformin
00:46:02 NAD Boosters
00:50:33 Increasing Blood Flow
00:53:20 Sleep
00:58:02 Overall Message: Keep your Brain Healthy
00:58:50 Next Week’s Episode and the Future of Medicine
01:01:21 Options for Subscription for Support

Links:
The cerebellum in the brain ages slowly: https://bit.ly/3JC9CLL
Neuronal cells have a lower epigenetic age: https://bit.ly/3HVZsVA
Sirt1 regulates aging in mice: https://bit.ly/3sGZPNC
Mediterranean diet and brain health: https://bit.ly/3uUpYuL
Mediterranean diet and dementia risk: https://bit.ly/34Igp7H
Aerobic exercise improves executive functioning: https://bit.ly/34Dv5oJ
Exercise and mouse models of neurodegenerative disease: https://bit.ly/3516IRn
Strength exercises elevate the expression of BDNF: https://bit.ly/3GTLqCs
Metformin enhances cognitive ability in fish: https://bit.ly/3sLtWn2
Alzheimer’s disease and metformin: https://bit.ly/3GSdTJ5
Metformin use correlates with a reduced risk of dementia: https://bit.ly/3GT0KPO
NAD boosting and Alzheimer’s disease: https://bit.ly/367C2P2
ALS, nicotinamide riboside, and pterostilbene: https://bit.ly/3Bm2VKN
Vascular aging and NAD in mice: https://bit.ly/34Uemgx
In mice, overexpressing Sirt1 in the brain extends lifespan: https://bit.ly/3HNRyh3
Sirt1 ameliorates amyotrophic lateral sclerosis in mice: https://bit.ly/3LvUWiO
Sirt1 protects against Alzheimer’s disease in mice: https://bit.ly/34KZXUe
Sirt1 and neuroprotection in a mouse model of Huntington’s disease: https://bit.ly/3BqymDJ
Sleep loss reduces lifespan in flies: https://bit.ly/3Jt6BgA
A single night of sleep deprivation increases amyloid-beta: https://bit.ly/3uSNGaU
All-cause mortality correlates with sleep duration: https://bit.ly/3rQl14f

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.