Latest videos
In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections.
#DavidSinclair #Longevity #SkinCare
Thank you to our sponsors:
Athletic Greens - https://athleticgreens.com/sinclair
Levels - https://levels.link/sinclair
InsideTracker - https://insidetracker.com/sinclair
Our Patreon page:
https://www.patreon.com/davidsinclair
Lifespan book:
https://amzn.to/3sUqurT
Lifespan podcast website: https://www.lifespanpodcast.com
Dr. David Sinclair Social:
Instagram - https://www.instagram.com/davidsinclairphd
Twitter - https://twitter.com/davidasinclair
Facebook - https://www.facebook.com/davidsinclairphd
Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com
Matthew LaPlante's Social:
Twitter - https://twitter.com/mdlaplante
Timestamps:
00:00:00 Launching Episode Six: Combating Cosmetic Aging & Improving Skin, Nails & Hair
00:02:54 Estrogen, Progesterone, and Menopause
00:09:51 Thanking the Sponsors
00:12:57 The Pinch Test, Epidermal Thinning, and Foot Ulcers
00:18:29 Skin and Biological Aging
00:23:19 Cellular Senescence, Ultraviolet Light, and Skin Aging
00:28:15 Collagen, Keratin, and Skin Health
00:33:38 A Quick Aside about Nails
00:34:45 Autophagy and Retinoids
00:36:57 Resveratrol, NAD Boosters, and Hyaluronic Acid
00:41:44 Botox, Skin Peels, and Microneedling
00:43:28 No Duh Stuff: Sun Damage, Smoking, Alcohol, and Bad Food
00:45:42 Hair Loss and Hair Graying
00:49:45 Topical Treatments, Pills, and Dihydrotestosterone
00:55:19 Frickin Laser Beams: Low-level Laser Therapy
00:57:59 Platelet-rich Plasma (PRP) Injections
01:00:11 Hair Aging, Stress, and Gray Hair Reversal
01:06:11 Targeting Aging Upstream
01:07:37 Today’s Takeaways
01:09:25 Subscription and Support Options
Links:
Human faces and mortality predictions: https://bit.ly/3rA0tgd
Biological age prediction in human skin: https://bit.ly/3LdDZcO
Senescent cells and lifespan in mice: https://go.nature.com/3HFO9Rh
Nail growth and aging: https://bit.ly/34tnSYb
Autophagy is a major regulator of aging: https://bit.ly/3uHh2Jr
Hyaluronan and cancer resistance: https://go.nature.com/3HHoyHK
Topical tretinoin and hair growth: https://bit.ly/3GCF0rl
Dihydrotestosterone levels correlate with mortality: https://bit.ly/3GBFFJJ
Eunuchs are especially long-lived: https://bit.ly/3ukL1GU
Human hair greying is linked to life stress: https://bit.ly/3J5adVU
Grey hair reversal in mice: https://bit.ly/3Li9F0J
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a "low energy state," which can be induced by a period of fasting, combats aging and promotes health. They also walk through research that points to the benefits of a mostly plant-based diet for slowing aging and offer key insights into when to eat and what to eat to maximize longevity.
#Food #DavidSinclair #Longevity
Thank you to our sponsors:
Levels - https://levels.link/sinclair
Athletic Greens - https://athleticgreens.com/sinclair
InsideTracker - https://insidetracker.com/sinclair
Our Patreon page:
https://www.patreon.com/davidsinclair
Lifespan book:
https://amzn.to/3sUqurT
Dr. David Sinclair Social:
Instagram - https://www.instagram.com/davidsinclairphd
Twitter - https://twitter.com/davidasinclair
Facebook - https://www.facebook.com/davidsinclairphd
Matthew LaPlante's Social:
Twitter - https://twitter.com/mdlaplante
Timestamps:
00:00:00 Introducing Episode Two: What to Eat & When to Eat for Longevity
00:01:10 Thanking the Sponsors
00:04:36 A Starting Place for Longevity: Eat Less Often
00:08:04 Caloric Restriction is an Evolutionarily Conserved Anti-Aging Strategy
00:09:52 Dietary Longevity Strategies are Accessible (and Save Money)
00:11:39 A Low Energy State Triggers a Genetic Pathway Involving Sirtuin Activation
00:13:10 NAD+ is Elevated by a Low Energy State
00:15:23 Fasting, mTOR, and AMPK
00:17:37 Data in Humans vs. Model Organisms
00:21:24 Evidence that Fasting is a Pro-longevity Intervention in Humans
00:24:00 Evidence that Fasting can Attenuate Human Disease
00:25:11 Different Fasting Regimens
00:29:42 Focus on Time-restricted Feeding (≥ 16 Hours of Fasting)
00:33:26 Continuous Glucose Monitors
00:34:24 Genetics Influence How an Intervention Affects Aging
00:36:51 A Trick for Fasting: Filling your Body with Fluids
00:38:44 Intermittent Fasting with Adequate Nutrition (IFAN)
00:40:00 Things to Avoid: Excess Sugar and Protein
00:45:16 Branched Amino Acids, Red Meat, and mTOR
00:47:53 Plant-Based Diets Protect Against Aging
00:51:44 The Okinawa Diet and Blue Zones
00:54:16 Xenohormesis
00:58:16 Main Takeaways
01:04:12 Obesity, Eating Habits, and Aging
1:05:54 Metabolic Winter Hypothesis
01:06:44 Preview for Episode 3: Beneficial Stress
01:07:23 Options for Subscription and Support
Links:
Dietary restriction extends lifespan in dogs - https://bit.ly/3FlDo4y
Intermittent fasting in patients with metabolic syndrome - https://go.nature.com/3FggKKZ
Alternate day fasting in healthy, non-obese humans - https://bit.ly/3HXGptH
Time-restricted feeding in humans with prediabetes - https://bit.ly/3ffZWct
A 24-hour fast reduces inflammasome activation in humans - https://bit.ly/3fwDc8t
Fasting and diabetes - https://bit.ly/3rdtRHQ
Intermittent energy restriction and multiple sclerosis - https://bit.ly/3HV7i1o
A fasting-mimicking diet in patients with breast cancer - https://go.nature.com/3flcbV2
Mouse genetics influence how diet affects lifespan - https://bit.ly/3qiBc9R
Vegetarian dietary patterns and human mortality - https://bit.ly/31OCtMq
A Mediterranean diet slows biological aging - https://bit.ly/3I1rcbd
Plant polyphenols regulate lifespan in yeast - https://go.nature.com/3HWWGiB
A Mediterranean diet is linked to reduced mortality - https://bit.ly/3fdDPDx
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks.
#Aging #DavidSinclair #Longevity
Thank you to our sponsors:
Athletic Greens - https://athleticgreens.com/sinclair
InsideTracker - https://insidetracker.com/sinclair
Levels - https://levels.link/sinclair
Our Patreon page:
https://www.patreon.com/davidsinclair
Lifespan book:
https://amzn.to/3sUqurT
Dr. David Sinclair Social:
Instagram - https://www.instagram.com/davidsinclairphd
Twitter - https://twitter.com/davidasinclair
Facebook - https://www.facebook.com/davidsinclairphd
Matthew LaPlante's Social:
Twitter - https://twitter.com/mdlaplante
Timestamps:
00:00:00 Introduction
00:03:14 Goal of the Lifespan Podcast
00:07:11 Acknowledgement of Sponsors
00:10:45 Aging is a Controllable Process that can be Slowed & Reversed
00:16:42 Organisms with Extreme Longevity
00:21:47 Genes that Regulate Aging: mTOR, AMPK, Sirtuins
00:21:55 mTOR & Rapamycin
00:24:33 AMP-activated protein kinase (AMPK) & Metformin
00:30:57 Sirtuin Proteins as Epigenetic Regulators of Aging
00:35:33 Ex-Differentiation
00:43:30 Measuring Aging - Biological Age vs. Chronological Age
00:49:30 "No Law That Says We Have To Age"
00:50:33 Episode Summary & Key Takeaways - Why Do We Age?
00:54:00 Information Theory of Aging
00:57:59 Aging is a Medical Condition
01:01:00 Aging Myths - Telomeres & Antioxidants
01:01:55 Options for Subscription and Support
Links:
Weapon fragments in bowhead whales - https://bit.ly/3eP7rqP
Rapamycin extends lifespan in mice - https://go.nature.com/3F0yud3
Targeting Aging with Metformin (TAME) Trial - https://bit.ly/3eU9ABk
Metformin improves healthspan and lifespan in mice - https://go.nature.com/3JSRZbs
Metformin reduces all-cause mortality - https://bit.ly/3pWNiWc
Reprogramming to restore vision - https://go.nature.com/335iysI
DNA methylation age - https://bit.ly/3sUAUYB
Genome-wide methylation profiles & human aging rates - https://bit.ly/3ETPXnK
Reversal of epigenetic aging in humans - https://bit.ly/3eUior3
Danish twins study - https://bit.ly/3eToU13
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
NOTE FROM TED: Research around aging discussed in this talk remains an ongoing field of study. Please do not look to this talk for health advice. TEDx events are independently organized by volunteers. The guidelines we give TEDx organizers are described in more detail here: http://storage.ted.com/tedx/ma....nuals/tedx_content_g
Have you ever wondered how long you will live? And if so, how could you change that number to live drastically longer? The science might be in your favor: follow David Sinclair, Australian biologist and professor of genetics at Harvard University, as he shares his research on slowing and reversing the process of aging in mice, and how the same technology may someday be transferable to humans. David Sinclair, Australian biologist and professor of genetics at Harvard University, shares his insightful research into the science of age reversal and anti-aging medicine.
David Sinclair, Australian biologist and professor of genetics at Harvard University, shares his insightful research into the science of age reversal and anti-aging medicine. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx
Lifespan.com is now live.
- Built by scientists.
- Built for you.
Living your longest, healthiest life starts with knowing what the science actually says. Lifespan connects you directly with the scientists advancing longevity — bringing trusted, evidence-based science, guidance, a first-of-its-kind Lifespan Magazine (written entirely by longevity scientists and thought leaders), the Lifespan show (a #1 Health & Fitness Podcast), and a global community, together in one place.
And we’re not just sharing the science. We’re helping advance it by supporting medical research and early-career scientists through the Lifespan Foundation (see disclaimer).
So join us at Lifespan.com. Life’s too short. Let’s change that, together.
#longevity #aging #research
Disclaimer: Lifespan Group and Lifespan Foundation (a 501(c)(3)) are independent entities and are not affiliated with, sponsored by, endorsed by, or acting on behalf of Harvard University, Harvard Medical School, or any of their affiliates.
All statements, opinions, commentary, and other content expressed or published by Lifespan, its team, contributors, guests, or representatives, whether on Lifespan.com, the Lifespan show, Lifespan Magazine, social media, or any other Lifespan platform, are solely those of the respective individuals and/or Lifespan. They do not represent, and should not be attributed to, Harvard University, Harvard Medical School, or any of their affiliates. Lifespan Foundation supports students and longevity projects and is not allowed to fund the Sinclair Lab. To directly fund the Sinclair lab, visit FriendsofSinclairlab.org
What if aging is more reversible than we once thought?
Season 2 of Lifespan with Dr. David Sinclair, A.O., Ph.D., explores the latest breakthroughs in longevity science - from epigenetic restoration to fasting, exercise, sleep, metabolism, and the emerging technologies that could help us live longer and healthier lives.
Drawing on more than 30 years of research and conversations at the frontier of science and medicine, Dr. Sinclair breaks down complex discoveries into practical, evidence-based insights designed to help you understand how the body ages - and what may be possible to slow, optimize, or even reverse aspects of that process.
This season features:
• New episodes on fasting, exercise, metabolic health, and longevity science
• The latest research on biological aging and cellular repair
• Practical tools for healthier living backed by scientific evidence
• New conversations around the future of medicine and human healthspan
We're building the world's largest longevity community, focused on supporting medical research and living longer, together. Join us at https://lifespan.com
Follow Lifespan:
Instagram: https://instagram.com/lifespan
X: https://x.com/JoinLifespan
Follow Dr. David Sinclair:
Instagram: https://instagram.com/davidsinclairphd
Threads: https://threads.net/@davidsinclairphd
X: https://x.com/davidasinclair
Bluesky: https://bsky.app/profile/david....sinclairphd.bsky.soc
LinkedIn: https://linkedin.com/in/davidsinclairphd
YouTube: https://www.youtube.com/@LifespanOfficial
Watch or listen on YouTube, Spotify, and Apple Podcasts.
In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters (these being NR, NMN, NAD IV drips and shots), resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted.
Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. We apologize for the confusion.
#DavidSinclair #Longevity #Lifespan
Thank you to our sponsors:
Levels - https://levels.link/sinclair
InsideTracker - https://insidetracker.com/sinclair
Athletic Greens - https://athleticgreens.com/sinclair
Our Patreon page:
https://www.patreon.com/davidsinclair
Lifespan book:
https://amzn.to/3sUqurT
Dr. David Sinclair Social:
Instagram - https://www.instagram.com/davidsinclairphd
Twitter - https://twitter.com/davidasinclair
Facebook - https://www.facebook.com/davidsinclairphd
Matthew LaPlante's Social:
Twitter - https://twitter.com/mdlaplante
Timestamps:
00:00:00 Kicking Off Episode Four: Longevity Molecules
00:02:15 Thanking the Sponsors
00:04:46 An Additional Boost Beyond Adversity Mimetics
00:05:52 Drugs vs. Supplements and Highlight Points
00:09:54 Longevity Molecules Target the Survival Circuit
00:11:33 NAD Boosters
00:13:32 Nicotinamide Riboside
00:21:26 Nicotinamide Mononucleotide
00:29:22 NAD Intravenous Drips
00:32:45 Bioavailability of NAD Boosters
00:33:40 NAD and Cancer
00:35:33 Resveratrol
00:42:26 Red Wine and The French Paradox
00:43:08 Fisetin and Quercetin
00:47:09 Rapamycin and Rapalogs
00:49:10 Spermidine
00:51:27 Metformin
01:00:27 Berberine
01:02:43 Dr. Sinclair’s Protocol for Longevity Molecules
01:08:51 Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge
01:09:52 Options for Subscription and Support
Links:
The Sinclair Lab website: https://sinclair.hms.harvard.edu/
Nicotinamide riboside is well-tolerated in humans: https://go.nature.com/3G1blbb
Nicotinamide riboside is a sirtuin-activator: https://bit.ly/3FUWWxa
Mice treated with nicotinamide riboside are longer-lived: https://bit.ly/3KD5L2h
Nicotinamide riboside protects mice against obesity: https://bit.ly/345E4hF
An inflammatory signature is attenuated by nicotinamide riboside: https://bit.ly/3Aum78I
Nicotinamide riboside, pterostilbene, and ALS: https://bit.ly/3nYdxK6
Nicotinamide mononucleotide combats diabetes in mice: https://bit.ly/3AwakXx
Aging is slowed by nicotinamide mononucleotide: https://bit.ly/344jGgW
Nicotinamide mononucleotide in prediabetic women: https://bit.ly/3H1vv6b
NAD and cancer in mice: https://go.nature.com/32xl1wp
Resveratrol protects mice against a high-calorie diet: https://go.nature.com/3G2pZyE
Resveratrol in patients with type 2 diabetes: https://rsc.li/3Aupk8h
Supplementing resveratrol in metabolic syndrome patients: https://bit.ly/3IE6C0Q
Fisetin enhances longevity in mice: https://bit.ly/3o10hom
Quercetin and fatty liver disease: https://bit.ly/3H4KWdF
Dasatinib and quercetin decrease senescent cell burden: https://bit.ly/35pCHuY
Mice fed rapamycin late in life live longer: https://go.nature.com/3F0yud3
Spermidine induces life extension and cardioprotection in mice: https://go.nature.com/3fXL5nn
Spermidine and older subjects with cognitive decline: https://bit.ly/3IG0MMy
Healthspan and lifespan in mice are improved by metformin: https://go.nature.com/3JSRZbs
Metformin, age-related diseases, and mortality: https://bit.ly/3KG0iaS
Targeting aging with metformin (TAME) trial: https://bit.ly/3eU9ABk
Treating mice with berberine extends lifespan: https://bit.ly/3AwkO9l
Lifespan in fruit flies is prolonged by berberine: https://bit.ly/3nYpwYt
Berberine and metabolic disorders: https://bit.ly/3KUpwCC
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
Ketone IQ: Visit https://ketone.com/IMPACT for 30% OFF your subscription order
AT&T Business: Switch to AT&T Business at business.att.com
Today on Impact Theory, Tom Bilyeu sits down with renowned Harvard biologist Dr Sinclair for a mind-bending exploration at the intersection of health, longevity, and artificial intelligence. In this episode, Dr Sinclair discusses revolutionary breakthroughs his lab is making in age reversal, revealing how AI is transforming the speed and scale of discovery in biology. Together, they unpack the latest science behind aging as an information problem, describe how cells might carry a youthful "backup" that could be reactivated, and share jaw-dropping advances—like growing mini human brains and reversing aging in mice and monkeys. If you want an inside look at the future of health and why we're living through the weirdest—and most exciting—moment in human history, you do not want to miss this episode.
About Lifespan:
Dr. David Sinclair founded Lifespan to deliver clear, science-backed health insights that help people live longer, more vibrant lives.
He's now building the world's largest community dedicated to extending human longevity well beyond today’s limits. Join early access at https://www.lifespan.com.
New episodes of Lifespan with Dr. David Sinclair -- the #1 health and wellness podcast in its first season -- are coming soon to YouTube, Spotify, Apple Podcasts, and Lifespan.com.
Sign up for my AI Masterclass: https://tombilyeu.com/ai-masterclass
Check us out wherever you get your podcasts:
Spotify:https://open.spotify.com/show/....1nARKz2vTIOb7gC9dusE
Apple: https://podcasts.apple.com/us/....podcast/tom-bilyeus-
Do you need my help?
STARTING a business: join me here inside ZERO TO FOUNDER (https://tombilyeu.com/zero-to-founder)
Get the exact systems, mindset shifts, and principles that built a $1B brand delivered straight to your inbox every week. Subscribe for free (https://tombilyeu.com)
Check out our Video game - Project Kyzen: (https://projectkyzen.io/)
Catch Me Streaming on Twitch - (https://twitch.tv/tombilyeu)
Link to IT discord: https://discord.gg/TZKJ2etPbT
Tom's Favorite Things List: https://amzn.to/41Ftt7e
FOLLOW TOM:
Instagram: https://www.instagram.com/tombilyeu/
Tik Tok: https://www.tiktok.com/@tombilyeu?lang=en
Twitter: https://twitter.com/tombilyeu
YouTube: https://www.youtube.com/@TomBilyeu
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
__________________________________________
This episode explores why humans are biologically built to move and what happens to the aging process when we don’t.
Drawing on evolutionary biology and the latest research, Dr. Sinclair traces physical activity back millions of years, explaining how humans evolved for endurance, why modern sedentary life creates a profound mismatch with our biology, and how exercise activates ancient cellular pathways involved in repair, resilience, metabolism, and longevity.
Dr. Sinclair breaks down what happens inside the body when we exercise, including the molecular responses that help us adapt to stress and influence the brain, immune system, metabolism, cardiovascular health, and even the way our cells age.
He also tackles some of the biggest questions in exercise science: Can exercise offset sitting all day? Do we compensate for calories burned during exercise? Why did humans evolve such extraordinary endurance? And could exercising with others provide benefits beyond physical fitness?
From our evolutionary past to the molecular machinery inside our cells, this episode reveals why movement is so deeply embedded in human biology – and why staying active may be one of the most powerful ways to keep that biology working as we age.
__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN
○ Withings: Get 10% off smart health devices at https://withings.com/LIFESPAN
__________________________________________
Legal & Medical Disclaimers
The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.
The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.
Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.
From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.
Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.
The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
__________________________________________
In this episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and pioneer in longevity research – explores the science of calorie restriction and fasting, two of the most studied interventions for healthy aging.
Drawing on decades of research, Dr. Sinclair explains how eating less – and eating less often – affects the biology of aging, why our evolutionary past may predispose many of us to weight gain, and what the latest human and animal studies reveal about lifespan, metabolism, and disease risk.
Whether you're interested in longevity, metabolism, or intermittent fasting, this episode provides an evidence-based look at one of the most powerful strategies for supporting health and longevity.
__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN
○ Withings: Get 10% off smart health devices at https://withings.com/LIFESPAN
__________________________________________
Legal & Medical Disclaimers
The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.
The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.
Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.
From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.
Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.
The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
__________________________________________
In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. - Professor of Genetics at Harvard Medical School and longevity scientist - and co-host Matthew LaPlante explore why we age, how aging begins long before its visible signs appear, and what we can do to slow aspects of cellular aging.
They break down key drivers - or “hallmarks” - of aging, including mitochondrial dysfunction, stem cell exhaustion, and declining communication between cells, and explain how these changes can affect energy, inflammation, and the body’s ability to repair itself.
They also explore practical strategies including exercise, cold exposure, and molecules such as berberine, curcumin, metformin, and resveratrol, alongside emerging research into mitochondrial replacement and stem cells.
Along the way, they tackle intriguing questions: When does biological aging begin? Why can identical twins age at different rates? Why does energy decline with age? And what can we do today to stay healthier for longer?
__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN
○ Withings: Get 10% off smart health devices at https://withings.com/lifespan
__________________________________________
Legal & Medical Disclaimers
The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.
The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.
Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.
From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.
Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.
The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
🎞️ This Is A Clip From Figuring Out Episode 562
Watch The Full Episode Here - https://www.figuringout.co/link/fo-562
• • •
☑️ Subscribe To Our Primary/Podcast Channel:
https://www.youtube.com/@rajshamani
☑️ Subscribe To Raj Shamani Shorts Channel:
https://www.youtube.com/@RajShamani.Shorts
📺 Watch Figuring Out Episodes On YouTube:
https://youtube.com/playlist?l....ist=PLE0Jo6NF_JYO5-p
🎧 Listen To Figuring Out Episodes On Spotify:
https://open.spotify.com/show/....736rhmW7vilNgkFFo8aD
• • •
Featuring - Dr. David Sinclair
In today’s episode, we sit down with Dr. David Sinclair, A.O., Ph.D., Longevity Scientist and Professor of Genetics, Harvard Medical School, to understand the science of aging and whether we can actually slow it down.
We discuss why our bodies age, what happens to our cells as we get older, and how genetics, lifestyle, and cellular health influence longevity. David explains the science behind reversing biological aging, the role of nutrition and exercise, and what emerging research could mean for extending both lifespan and healthspan.
The conversation also explores what we can do today to stay healthier for longer and where the science of longevity is heading.
• • •
About Raj Shamani
Raj Shamani is the Founder Of Figuring Out Media. He's an Entrepreneur, Content Creator, Investor, and a Renowned Keynote Speaker. Raj has emerged as one of the Youngest Influencers in the Indian creator economy.
To Know More,
Follow Raj Shamani On ⤵︎
Instagram @RajShamani
https://www.instagram.com/rajshamani
Twitter @RajShamani
https://twitter.com/rajshamani
Facebook @ShamaniRaj
https://www.facebook.com/shamaniraj
LinkedIn - Raj Shamani
https://in.linkedin.com/in/rajshamani
• • •
#figuringout #rajshamaniclips #podcast #drpal
About Raj Shamani Clips
Raj Shamani Clips is your one-stop destination to become 1% smarter every day. This channel will help you grow daily so that you live and love better. We are on the mission to help everyone achieve their ‘Indian Dream’ through Figuring Out. We promise you that you will learn new things around business, marketing, politics and everything around India. Subscribe to our channel and grow with us.
#keepfiguringout
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
__________________________________________
In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and longevity scientist – details how to exercise for a longer, healthier life.
Drawing on the latest research, Dr. Sinclair explains why exercising for longevity isn’t the same as training for peak athletic performance – including how much exercise you really need, which types matter most as you age, and whether more exercise is always better.
He also breaks down the key fitness metrics for longevity – including VO2 max, grip strength, resting heart rate, and heart rate variability (HRV) – and why cardiorespiratory fitness may predict mortality more strongly than smoking, diabetes, or hypertension.
Lastly, Dr. Sinclair tackles some of the most common questions about exercise science: What’s the best time of day to work out? Should you drink coffee beforehand? Should men and women train differently? How should exercise change as you age?
Whether you're just getting started or already exercise regularly, this episode offers a practical, evidence-based guide on what to do to stay healthier for longer.
__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN
○ Withings: Get 10% off smart health devices at https://withings.com/LIFESPAN
__________________________________________
Legal & Medical Disclaimers
The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.
The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.
Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.
From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.
Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.
The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
__________________________________________
In this first episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. - Professor of Genetics at Harvard Medical School and pioneer in longevity research - returns and explores one of the most consequential questions in science: How can aging be slowed or reversed?
Drawing on more than 25 years of research at the forefront of aging biology, Dr. Sinclair explains why humanity has entered a revolutionary period. Advances in science and technology have converged and transformed aging into a promising target for intervention.
This episode is a sweeping introduction to the science, breakthroughs, and emerging technologies that are fundamentally reshaping how we think about aging, disease, and the future of human health.
__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN
○ Withings: Get 10% off smart health devices at https://withings.com/LIFESPAN
__________________________________________
Legal & Medical Disclaimers
The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.
The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.
Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.
From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.
Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.
The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
What are the most important things you can do today to live longer and stay healthier while doing it?
In this final Lifespan Rewind episode, Dr. David Sinclair, A.O., Ph.D., a Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, revisits the most surprising insights from his #1-ranked Season 1 series, combining updated commentary with key moments from across all eight episodes. The result is a thought-provoking, focused, practical guide to the science of longevity – grounded in evidence and designed for real-world application.
Whether you're new to longevity science or looking to refine your approach, this episode brings together the most important principles in one place so you can better understand not just what to do, but why it matters.
At Lifespan, our mission is to help you and your loved ones live longer, healthier lives while supporting medical research aimed at breakthroughs to extend all our lives.
Join us at: https://lifespan.com. We’re building the world’s largest longevity community who will grow, learn, and live longer together.
Subscribe here for new Lifespan show episodes every two weeks.
__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in strong science – and products our team has personally used for many years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode – from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat content and muscle gains (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan with code LIFESPAN
○. WHOOP: Get a free WHOOP band plus one month free at https://join.whoop.com/LIFESPAN with code LIFESPAN
○. Withings: Explore their smart health devices at https://withings.com/LIFESPAN
__________________________________________
Legal & Medical Disclaimers
The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.
The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.
Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.
From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.
Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.
The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
__________________________________________
This Lifespan episode explores how what we eat shapes how we age - from inflammation and blood sugar to the trillions of microbes living in our gut. Dr. Sinclair explains how diet affects key biological processes tied to metabolism, health, and longevity.
Dr. Sinclair breaks down what sugar does inside the body, including glycation - the process by which sugar attaches to proteins and disrupts their function. The conversation also explores why inflammation rises with age, how the gut microbiome changes over time, and why our ability to sense and respond to nutrients can decline as we get older.
Most importantly, Dr. Sinclair explains what we can do about it - from reducing dietary drivers of inflammation and excess sugar to supporting gut health and the nutrient-sensing pathways linked to longevity.
__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN
○ Withings: Get 10% off smart health devices at https://withings.com/LIFESPAN
__________________________________________
Legal & Medical Disclaimers
The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.
The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.
Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.
From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.
Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.
The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives - while supporting medical research into breakthroughs to improve all lives.
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
__________________________________________
In this second installment of Lifespan's two-part series on calorie restriction and fasting, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and a pioneer in longevity research – explores how to fast effectively for health and longevity.
Drawing on decades of research and the latest scientific evidence, Dr. Sinclair explains how to approach fasting effectively, what happens inside your body at the 12-, 24-, and 48+-hour marks, how to overcome common plateaus, and the key considerations for women, men, and people at different stages of life.
Whether you're new to fasting or looking to refine your approach, this episode provides a practical, evidence-based guide to using fasting to support metabolism, cellular repair, and healthy longevity.
__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN
○ Withings: Get 10% off smart health devices at https://withings.com/LIFESPAN
__________________________________________
Legal & Medical Disclaimers
The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.
The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.
Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.
From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.
Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.
The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
What are the most important things you can do today to live longer and stay healthier while doing it?
In this first Lifespan Rewind episode, Dr. David Sinclair, A.O., Ph.D., a Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, revisits the most impactful insights from his #1-ranked Season 1 series, combining updated commentary with key moments from across all eight episodes. The result is a focused, practical guide to the science of longevity – grounded in evidence and designed for real-world application.
This episode covers:
● 0:00 What to eat – and what to avoid – for long-term health
● 20:17 How to think about exercise for longevity (not just performance)
● 29:22 The role of cold and heat exposure
● 36:21 Which supplements may support healthy aging & the tools and protocols Dr. Sinclair personally uses in his own routine
● 41:50 Emerging medical interventions and what the science actually shows
Whether you're new to longevity science or looking to refine your approach, this episode brings together the most important principles in one place so you can better understand not just what to do, but why it matters.
At Lifespan, our mission is to help you and your loved ones live longer, healthier lives while supporting medical research aimed at breakthroughs to extend all our lives.
Join us at: https://lifespan.com. We’re building the world’s largest longevity community who will grow, learn, and live longer together.
Subscribe here for new Lifespan show episodes every two weeks.
__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in strong science – and products our team has personally used for many years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode – from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat content and muscle gains (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan with code LIFESPAN
○. WHOOP: Get a free WHOOP band plus one month free at https://join.whoop.com/LIFESPAN with code LIFESPAN
○. Withings: Explore their smart health devices at https://withings.com/LIFESPAN
__________________________________________
Legal & Medical Disclaimers
The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.
The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.
Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.
From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.
Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.
The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.
We’re building the world’s largest longevity community: Join us at https://lifespan.com.
Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
__________________________________________
Could an amino acid found in asteroids and comets, that’s sweet enough to replace sugar, also help us live longer? In this episode, David and Matt explore Glycine, one of life’s simplest building blocks, and why it’s attracting attention in aging research. From building collagen to blood sugar control, heart health, memory, and recovery after stroke, its potential reaches surprisingly far. They unpack studies linking glycine to multiple hallmarks of aging and longer lifespans in animal models and ask what it would take to show these benefits in humans.
__________________________________________
Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.
Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).
If you’d like to learn more or try these tools:
○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN
○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN
○ Withings: Get 10% off smart health devices at https://withings.com/lifespan
__________________________________________
Legal & Medical Disclaimers
The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.
The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.
Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.
From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.
Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.
The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.
Glass is glass. A bit of a rant/explainer/PSA
For more lies tech companies tell: https://youtu.be/JstGCPsj9wg?si=AUjR2F7aJNuAS85U
MKBHD Merch: http://shop.MKBHD.com
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
Thanks Antigravity for sponsoring this video! Get 25% off the A1 at https://geni.us/lQlFcj for a limited time, and get 20% off accessories during Prime Day! Also, the first 25 people get a free flight battery and a double-lens replacement kit with their A1 purchase.
MKBHD Merch: http://shop.MKBHD.com
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
AI...Siri... magic mouse... we talk about it all
WWDC 2024 Recap: https://youtu.be/qkYoBNdcXBU
MKBHD Merch: http://shop.MKBHD.com
Tech I'm using right now: https://www.amazon.com/shop/MKBHD
Intro Track: Logic https://logic.lnk.to/DejaVu
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
0:00 AI vs Apple Intelligence
4:30 AI vs Privacy and ChatGPT
6:35 Standalone AI Devices
8:42 Legacy
10:06 Blind Ranking/Retrospective
Spending 48 Hours With MKBHD & The Studio At The iPhone Duo Event
Chapters:
0:00 Don’t Skip This Intro
3:00 Are we missing this flight?
4:16 That’s the In-N-Out
5:04 Going for a run before Apple
6:26 New beginnings
7:00 What Apple announced
8:14 Man on the street podcast begins
9:13 Something better than iPhone Duo
9:55 Marques’ video has a big problem
10:57 Going to the club
11:22 First Impressions video goes live
12:28 You may enter
13:02 Back to Apple
Shop the merch:
https://shop.mkbhd.com
Join the Discord:
https://discord.gg/mkbhd
Music licensed from Epidemic Sound:
https://share.epidemicsound.com/thestudioGEN25
Follow The Studio:
https://twitter.com/TheStudio
https://www.instagram.com/thestudio/
Follow the staff:
Marques Brownlee https://twitter.com/MKBHD
Olivia Bransford https://instagram.com/@livbransford
Adam Molina https://www.threads.com/@parmesanpapi17
Alex Wolfe https://bsky.app/profile/alexwolfe.bsky.social
Andrew Manganelli https://www.instagram.com/andrew_manganelli
Brandon Havard https://www.instagram.com/havard.jpg/
David Imel https://instagram.com/DurvidImel
Ellis Rovin https://instagram.com/ellisrovin
Harper Makowsky https://instagram.com/harper_mak
Jono Tan https://www.instagram.com/burntbanana/
Mariah Zenk https://www.instagram.com/totallynotabusinessacc/
Michael Emerick https://www.instagram.com/emerickm/
Miles Somerville https://www.instagram.com/carswithmiles
Rich Ho https://instagram.com/richontrack
Rufus Mullhaput https://www.instagram.com/rmullhaupt/
Tim McMahon https://www.instagram.com/timmcmahonn/
Vinh Dang https://instagram.com/danggvinh
Equipment used in this video and others:
Canon EOS C70: https://geni.us/AtpxW
Canon RF 15-35mm f/2.8L: https://howl.me/chHqd63eV8A
Canon RF 28-70mm f/2.8L: https://geni.us/Tbimi
Sennheiser MKH-416: https://geni.us/jYxRVj
Sennheiser ME 2 lav: https://geni.us/0bpKiZX
PowerDeWise lav: https://geni.us/SRX1Th
Zoom F8n Pro: https://geni.us/tuv7o8
Hollyland Lark Max: https://geni.us/mkJRt7
Shot by Rich Ho
Edited by Rich Ho & Rufus Mullhaput
Technical Producer & Colorist - Rich Ho
Audio by Rufus Mullhaput
Graphics by Olivia Bransford & Tim McMahon & Michael Emerick
The new iPhone 16e costs $599. Who is it for?
Save 15% when you bundle a dbrand Prism and Grip case at https://dbrand.com/bundle
Affiliate Links:
Apple iPhone 16e: https://geni.us/6rPErQ3
Apple iPhone 15 Pro: https://geni.us/aSjdqeY
MKBHD Merch: http://shop.MKBHD.com
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
Phone provided by Apple for review.
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
There have been countless Galaxy S phones in 14 years. Let's take a look at every single one of them!
Get a dbrand grip case for your Galaxy S 24 at https://dbrand.com/samsung-galaxy
0:00 Intro
3:13 Galaxy S 1
6:20 Galaxy S 2
7:35 Galaxy S3
9:45 Galaxy S4
12:40 Galaxy S5
14:47 Galaxy S6/Edge
19:24 Galaxy S7
21:22 Galaxy S8
25:40 Galaxy S9
27:77 Galaxy S10/S10e
30:35 Galaxy S20/FE
33:40 Galaxy S21
34:57 Galaxy S22
36:24 Galaxy S23
37:59 Galaxy S24
39:46 The Graphs!
MKBHD Merch: http://shop.MKBHD.com
Tech I'm using right now: https://www.amazon.com/shop/MKBHD
Intro Track: http://youtube.com/20syl
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
That time the FBI visited the studio...
Storytime podcast episode coming soon: https://youtube.com/Waveform
The original Escobar phone video: https://youtu.be/O8FJSjy3bXA
https://sifted.eu/articles/esc....obars-ceo-who-sued-k
MKBHD Merch: http://shop.MKBHD.com
Tech I'm using right now: https://www.amazon.com/shop/MKBHD
Intro Track: http://youtube.com/MKBHD
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
The modular Macbook Pro for Linux users. Color me impressed.
MKBHD Merch: http://shop.MKBHD.com
Framework 13 Pro: https://geni.us/SVkxq
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
Laptop provided by Framework for review.
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
New iPhones are officially here! Marques, Andrew, and David talk about the new iPhone 18 Pro phones and the newest foldable on the block, the iPhone Duo. There were also some interesting updates to the new AirPods 5 and Apple Watch Series 12/Apple Watch Ultra 4, so they spend some time discussing all of the updates as well. Of course, we wrap it all up with trivia. Enjoy!
Chapters:
00:00:00 - Intro
00:02:08 - Apple's New CEO
00:03:30 - AirPods 5
00:06:24 - Apple Watch Series 12 & Apple Watch Ultra 4
00:35:46 - Airbnb (Sponsored)
00:36:36 - Granola AI (Sponsored)
00:37:30 - iPhone 18 Pro
01:07:35 - Square (Sponsored)
01:08:36 - Shopify (Sponsored)
01:09:35 - iPhone Duo
01:42:12 - Trivia Scores
Links:
MKBHD - iPhone 18 Pro/Duo Impressions video: https://youtu.be/Od6M0AXpcxQ
Apple Watch Paper: https://www.apple.com/health/p....df/Heart_Rate_Accura
This episode brought to you by:
Airbnb: https://www.airbnb.com
Granola AI: https://www.granola.ai/waveform
Shopify: https://www.shopify.com/waveform
Square: https://www.square.com/go/waveform
Follow us on socials:
Marques: https://www.threads.net/@mkbhd
Andrew: https://www.threads.net/@andrew_manganelli
David: https://www.threads.net/@davidimel
Adam: https://www.threads.net/@parmesanpapi17
Ellis: https://twitter.com/EllisRovin
Waveform Threads: https://www.threads.net/@waveformpodcast
Waveform Instagram: https://www.instagram.com/waveformpodcast/?hl=en
Waveform TikTok: https://www.tiktok.com/@waveformpodcast
Join the Discord:
https://discord.gg/mkbhd
Intro/Outro music by 20syl:
https://bit.ly/2S53xlC
Waveform is part of the Vox Media Podcast Network.
Marques Brownlee is BACK for a very special Hot Ones Reunion. For more than a decade, he's been YouTube's tech consigliere with his channel MKBHD, which boasts 17 million subscribers. Check out his podcast Waveform, as well as his brand-new sneaker collaboration with Atoms, the Model 251. But how will he do in Round 2 against the wings of death? Find out as Marques reunites with Sean Evans and discusses tech pet peeves, fast cars, and Mr. Beast's studio.
BUY HOT ONES HOT SAUCE NOW: https://fwfea.st/hotsauces
TRY THE HOT ONES BONELESS CHICKEN BITE CHALLENGE: https://fwfea.st/chickenbites
BUY HOT ONES TRUTH OR DAB: THE GAME: http://truthordabgame.com
SHOP HOT ONES MERCH: https://bit.ly/2AIS271
SIGN UP FOR THE HOT ONES MONTHLY HOT SAUCE SUBSCRIPTION: https://bit.ly/2veY50P
SIGN UP FOR THE FIRST WE FEAST NEWSLETTER: http://firstwefeast.com/signup
SUBSCRIBE TO FIRST WE FEAST ON YOUTUBE: http://goo.gl/UxFzhK
MAKE A DIFFERENCE BY DONATING TO COMMON THREADS, THE OFFICIAL CHARITY PARTNER OF HOT ONES: https://www.commonthreads.org/firstwe...
Check out more of First We Feast here:
http://firstwefeast.com/
http://instagram.com/firstwefeast
http://instagram.com/hotones/
https://twitter.com/firstwefeast
https://www.facebook.com/FirstWeFeast
In this clip, Marques, Andrew, and David give their instant reactions to the iPhone Duo live from Apple Park.
Watch full episode: https://youtu.be/Jm-6iviCl3k
Follow us on socials:
Marques: https://www.threads.net/@mkbhd
Andrew: https://www.threads.net/@andrew_manganelli
David: https://www.threads.net/@davidimel
Adam: https://www.threads.net/@parmesanpapi17
Ellis: https://twitter.com/EllisRovin
Waveform Threads: https://www.threads.net/@waveformpodcast
Waveform Instagram: https://www.instagram.com/waveformpodcast/?hl=en
Waveform TikTok: https://www.tiktok.com/@waveformpodcast
Join the Discord:
https://discord.gg/mkbhd
Intro/Outro music by 20syl:
https://bit.ly/2S53xlC
Waveform is part of the Vox Media Podcast Network.
Behind the wheel and every detail and spec of the new "Beast Mode" Cybertruck from Tesla!
Get Ridge's Carry-On and more at https://ridge.com/MKBHD and use code MKBHD for 10% off
Get our merch: http://shop.MKBHD.com
Get discounts off most Tesla products with my affiliate link: http://ts.la/marques8135
Tech I'm using right now: https://www.amazon.com/shop/MKBHD
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
0:00 The Numbers/Specs
3:42 Differences vs the Original Cybertruck
4:30 Removable Aerocap Wheel
6:12 Pointy Stainless Steel/Build Quality
8:12 Powered truck Bed and Tonneau Cover
13:00 Doors with no handles
14:53 The Nose/Frunk
16:55 Ridge (Sponsor)
17:34 Interior Layout
22:16 The Back Seat Trick
23:54 Vehicle Controls + Steering Wheel
28:56 The Insane Steering
30:57 Driving the Cybertruck
35:43 World’s Largest Windshield Wiper
36:17 800V System
37:18 Range Extender
37:57 Final Thoughts
Move the needle.
ALL LINKS BELOW
Neil Degrasse Tyson's post: https://www.haydenplanetarium.....org/tyson/commentary
Resources:
https://blacklivesmatters.carrd.co/#business
Creators:
UrAvg Consumer (Tech): https://youtube.com/user/UrAvgConsumer
CalebCity (Comedy): https://youtube.com/user/GizzlyB3aver
Roberto Blake (Business): https://youtube.com/user/robertoblake2
Jacques Slade (Shoes): https://youtube.com/user/kustoo
Krystal Lora (Tech): https://youtube.com/user/thekrystallora
LamarrWilson (Comedy/Tech): https://youtube.com/user/wilsontech1
TechMeOut (Tech): https://youtube.com/user/TechMe0ut
Morgan Cooper (Filmmaking): https://youtube.com/user/CooperFilmskc
Zach Anderson (Tech): https://youtube.com/user/EzTech231
StarTalk (Science): https://youtube.com/user/startalkradio
Miles Somerville (Tech): https://youtube.com/channel/UC....rUuy7XGDYAAA1Xz9oO6p
RDCworld1 (Comedy): https://www.youtube.com/user/RDCworld1
Trevor Wentt (Lifestyle): https://youtube.com/user/TWentt37
Ska Tune NEtwork (Music): https://youtube.com/channel/UC....ji2l5wcs6GoYJY1GgG_s
Victor Kamanga (Tech): https://youtube.com/user/TechnologyIsLife
Jarvis Johnson (Commentary): https://youtube.com/user/VSympathyV
Flossy Carter (Tech): https://youtube.com/user/FLOSSYCARTER
Pixel 11 proves Google is going all in in one thing.
Enter for free for a chance to win $100,000 or 1 of 3 cars at https://ridge.com/MKBHD
MKBHD Merch: http://shop.MKBHD.com
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
Phones provided by Google for review.
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
Macbook Neo is only $600 bucks, but it's incredibly capable and compelling at this price
Check out dbrand skins for your MacBook at https://dbrand.com/retro-macbooks
That shirt! http://shop.MKBHD.com
(Affiliate Link) MacBook Neo: https://geni.us/JGI8B3f
Podcast: http://youtube.com/Waveform
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
MacBook Neo provided by Apple for review.
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
Everything you need to know about using Apple Vision Pro
Vision Pro Review: https://youtu.be/86Gy035z_KA
Apple's Forbidden words: https://youtu.be/kvN5_GXlg2Y?si=x4J7EDrLZOId2fh6
MKBHD Merch: http://shop.MKBHD.com
Tech I'm using right now: https://www.amazon.com/shop/MKBHD
Intro Track: Jordyn Edmonds http://smarturl.it/jordynedmonds
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
Headset provided by Apple for review.
0:00 Intro
1:14 This is a VR headset
4:23 The Battery
6:21 The Controls
8:24 VisionOS
10:21 Passthrough
12:37 Full Immersion
13:45 The Keyboard
15:03 What Does It Actually Do?
18:44 The "Killer App"
21:38 Mac Virtual Display
23:53 The Eyes
27:16 Personas
32:12 Facetimes
35:35 Review Preview
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
In this clip, Marques, Andrew, and David give their initial impressions with the iPhone 18 Pro the day after getting hands-on with the devices at Apple Park!
Watch full episode: https://youtu.be/Jm-6iviCl3k
Follow us on socials:
Marques: https://www.threads.net/@mkbhd
Andrew: https://www.threads.net/@andrew_manganelli
David: https://www.threads.net/@davidimel
Adam: https://www.threads.net/@parmesanpapi17
Ellis: https://twitter.com/EllisRovin
Waveform Threads: https://www.threads.net/@waveformpodcast
Waveform Instagram: https://www.instagram.com/waveformpodcast/?hl=en
Waveform TikTok: https://www.tiktok.com/@waveformpodcast
Join the Discord:
https://discord.gg/mkbhd
Intro/Outro music by 20syl:
https://bit.ly/2S53xlC
Waveform is part of the Vox Media Podcast Network.
This TECNO 0mm "borderless" concept phone actually has some interesting quirks
MKBHD Merch: http://shop.MKBHD.com
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
The new $599 M4 Mac Mini is really good. In more than one way.
MKBHD Merch: http://shop.MKBHD.com
Apple Mac Mini M4: https://geni.us/XAWA0
Tech I'm using right now: https://www.amazon.com/shop/MKBHD
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
That wallpaper: https://geni.us/aWrWc
Computer provided by Apple for review.
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
Apple lost the AI race. Actually, Apple won the AI race. Wait.
That shirt: http://shop.MKBHD.com
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
This is the best iPhone in years. Which can have an interesting effect on the rest of the lineup...
MKBHD Merch: http://shop.MKBHD.com
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
Phone provided by Apple for review.
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
The Apple Watch Ultra is $800, which makes it worth it only for a certain set of people...
Grab an MKBHD x Moment Apple Watch leather strap: https://mkbhd.com
Waveform podcast interviews: https://youtu.be/vGlbCM2coDU?t=2762
Check out the Apple Watch Ultra at https://geni.us/BslguaO
Check out the Apple Watch Series 8 at https://geni.us/lBcRAy
Tech I'm using right now: https://www.amazon.com/shop/MKBHD
Dive computers: https://www.divein.com/diving/dive-computer/
Intro Track: http://youtube.com/20syl
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
Watch provided by Apple for review.
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
Every year, a new Pixel, and new hopes and dreams...
Protect your new Pixel 11 or old Pixel 10 with dbrand at https://dbrand.com/shop/pixel11
Affiliate Links:
Pixel 11 Pro: https://geni.us/iypnawz
Pixel 11 Pro XL: https://geni.us/Jfybl
Pixel 11 Pro Fold: https://geni.us/XaTcge
Pixel Watch 5: https://geni.us/2s9sEq
MKBHD Merch: http://shop.MKBHD.com
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
This is a really easy phone to fall in love with. Beware.
Enter to win $100,000 USD or 3 cars for free at https://ridge.com/MKBHD
(Affiliate Link) Samsung Galaxy Z Fold 8: https://geni.us/GEv50B
MKBHD Merch: http://shop.MKBHD.com
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
Phone provided by Samsung for review.
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
NO PURCHASE NECESSARY. Open only to legal residents of the promotion territory, who have reached the age of majority in their jurisdiction of residence. Void elsewhere & where prohibited by law. Enter by 9:00 a.m. USPT on 8 September 2026. 2 winners, prizes total ARV: up to approx. $380,000 USD / approximately $539,165 CAD / £284,170 / $547,515 AUD / €333,038.Skill-testing question required in CA. See Official Rules at https://ridge.com/pages/rules for complete eligibility, entry instructions, how to enter without ax purchase, entry limits, prize details, odds, and restrictions. Sponsor: The Ridge Wallet LLC.
Is the Fitbit Air the true Whoop 5.0 killer?
MKBHD Merch: http://shop.MKBHD.com
Affiliate Links
Fitbit Air: https://geni.us/W24DGJY
Whoop: https://geni.us/0vkguAL
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
Fitbit provided by Google for review.
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
Samsung's wide fold is surprisingly nice to use. And everything is more expensive.
Protect your next Samsung Flip or Fold with dbrand at https://dbrand.com/shop/fold8
Affiliate Links:
Samsung Galaxy Z Fold 8: https://geni.us/GEv50B
Samsung Galaxy Z Fold 8 Ultra: https://geni.us/kWg2rl3
Samsung Galaxy Z Flip 8: https://geni.us/2An1N
MKBHD Merch: http://shop.MKBHD.com
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
I said yes to every review request I got for an entire month. I'm sorry? You're welcome?
Thanks Best Buy for sponsoring this video. You can find the tech upgrades you need to elevate your daily life at https://www.bestbuy.com/discover
MKBHD Merch: http://shop.MKBHD.com
DC Rainmaker Garmin CIRQA video: https://youtu.be/2K4x0CnuQug?si=9k68ymP8IUkciJUE
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
0:00 Intro
2:01 Xbook Laptop
5:02 Garmin CIRQA
6:51 Smart Toilet Seat
8:29 The Busy Bar
9:50 Beni Robot
13:33 Fan Mouse
15:02 Personal EKG
16:33 Honor Robot Phone
18:27 "AI Powered" Chair
21:03 Skullcandy Headphones
23:05 Gaming PC
25:24 Sony "True RGB" TV
28:19 What we learned
Tesla held a Cybercab event today and it was kinda weird...
Original Robotaxi Impressions: https://youtu.be/fgm5uZaS3-E
(I will definitely be donating in January anyway)
MKBHD Merch: http://shop.MKBHD.com
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
Apple Watch series 12 has a new "Audio Intelligence" feature, let's talk about it
Apple vs the AI Race: https://youtu.be/eWKY0OnPByg
MKBHD Merch: http://shop.MKBHD.com
Apple wearable study: https://www.apple.com/health/p....df/Heart_Rate_Accura
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
Watch provided by Apple for review.
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
A few new thoughts from the days after the Duo unveil.
That shirt: http://shop.MKBHD.com
The full iPhone Duo Hands-on: https://youtu.be/Od6M0AXpcxQ
Playlist of MKBHD Intro music: https://goo.gl/B3AWV5
~
http://twitter.com/MKBHD
http://instagram.com/MKBHD
http://facebook.com/MKBHD
Axios, the most popular HTTP library with over 100 million weekly downloads, was just hijacked in one of the most sophisticated supply chain attacks in history. A hacker took over the lead maintainer's npm account, injected a phantom dependency that deploys a cross-platform remote access trojan in 1.1 seconds, and the malware erases itself leaving no trace. I break down exactly how it happened, explain what a supply chain attack is, and show you how to check if YOUR system is affected.
npm supply chain attack, axios hacked, axios npm compromised, supply chain attack explained, npm install malware, remote access trojan, axios 1.14.1, plain-crypto-js, npm security, javascript security, open source security, postinstall script attack, supply chain hack 2026
TIMESTAMPS:
0:00 - npm install just became DANGEROUS
0:41 - How the attack happened
0:52 - What is Axios? (and why you probably have it)
1:39 - The account takeover
2:20 - The ONE line of code that did it all
3:06 - How it was discovered
3:32 - The postinstall dropper
4:08 - The RAT payload (Mac, Windows, Linux)
4:28 - The self-destruct (no evidence left)
4:40 - What IS a supply chain attack?
4:55 - The coffee analogy
5:51 - Are YOU affected? Let's check together
6:34 - Checking for the RAT on your system
6:51 - What to do if you're compromised
7:50 - Prayer
9:19 - BONUS: Pikachu explains supply chain attacks
ALL COMMANDS, DETECTION SCRIPTS, IOCs, AND REMEDIATION:
https://github.com/theNetworkC....huck/axios-attack-gu
Quick check:
npm list axios
npm list -g axios
BAD VERSIONS: 1.14.1 and 0.30.4
SAFE VERSIONS: 1.14.0 and 0.30.3
One command that would have BLOCKED this attack:
npm config set min-release-age 3
RESOURCES:
Socket.dev (first to detect): https://socket.dev/blog/axios-....npm-package-compromi
StepSecurity deep dive: https://www.stepsecurity.io/bl....og/axios-compromised
GitHub Issue: https://github.com/axios/axios/issues/10604
Huntress Blog: https://www.huntress.com/blog/....supply-chain-comprom
John Hammond Video: https://youtu.be/A58cV17avpM
John Hammond Livestream: https://www.youtube.com/watch?v=A-KpP-6Dt8E
SUPPORT NETWORKCHUCK:
NetworkChuck Academy: https://academy.networkchuck.com
FOLLOW ME EVERYWHERE:
Twitter: https://twitter.com/networkchuck
Instagram: https://www.instagram.com/networkchuck
TikTok: https://www.tiktok.com/@networkchuck
Discord: https://discord.gg/networkchuck
READY TO LEARN??
NetworkChuck Academy: https://academy.networkchuck.com
YouTube Membership: https://www.youtube.com/networkchuck/join
#npm #supplychain #cybersecurity
